Treatment of chronic lymphocytic leukemia with bendamustine in an <scp>HIV</scp>‐infected patient on antiretroviral therapy: a case report and review of the literature

Shimada, Naoki; Kikuchi, Yuji; Ohno, Nobuhiro; Koibuchi, Tomohiko; Oyaizu, Naoki; Uchimaru, Kaoru; Tojo, Arinobu

doi:10.1002/ccr3.244

Cited by 5 publications

(1 citation statement)

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“…Similar low occurrences of concurrent HIV and CLL have been reported in other African populations. 4,30,40,41 In this study, HIV-positive CLL patients were aged ranging from 43 to 50 years, which is considerably lower than the mean age of 66.79 years at CLL diagnosis in the overall cohort. Notably, the differences in the ages of risk for HIV, a disease of younger people, 42 and for CLL, a disease of older people, could be possible factors behind the uncommon overlap between the two diseases.…”

Section: Human Immunodeficiency Virus Statusmentioning

confidence: 85%

Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)

Musaigwa

Grewal

Abayomi

et al. 2021

South African Journal of Oncology

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Background: Chronic lymphocytic leukaemia (CLL) is a common lymphoproliferative disorder in developed countries. However, this condition is rare in Africa and there is a paucity of information on CLL, specifically on the continent.Aim: This study described, retrospectively, the frequency, demographics and laboratory features of CLL cases diagnosed from 2011 to 2016.Setting: Department of Pathology, National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town.Methods: A retrospective analysis was performed for all CLL diagnoses made between 01 January 2011 and 31 December 2016.Results: Eighty CLL cases were diagnosed between 2011 and 2016. Men and women presented with the disease equally (48.8% vs. 51.2%, p 0.05). The mean age at diagnosis was 66.79 years (range of 37–95 years) and the modal age range (36.3%) was 60–69 years. Men presented with the disease at a significantly younger age than women (mean = 64 years vs. mean = 69.5 years, p 0.05). There were three (3.75%) human immunodeficiency virus (HIV)-positive patients (age range 43–50 years). Chromosome 13q14 deletion was found in 6 out of 19 patients (31.6%). Trisomy 12 and deletion 11q22 were found in 5 out of 21 (24%) and 7 out of 21 (33.3%) patients, respectively. Deletions 13q34 and 17p were negative for 6 and 20 patients, respectively.Conclusion: Chronic lymphocytic leukaemia at our facility presented equally in men and women. Men presented with the disease at a younger age than women. Additionally, our findings suggested that HIV is uncommon amongst CLL patients tested for HIV.

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Section: Human Immunodeficiency Virus Statusmentioning

confidence: 85%