Kanerva’s Occupational Dermatology 2019
DOI: 10.1007/978-3-319-68617-2_93
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Treatment of Chronic Hand Eczema: Other Immunomodulating Therapies

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Cited by 4 publications
(4 citation statements)
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“…Efficacy and toxicity of azathioprine are associated with the activity of the enzyme thiopurine methyltransferase [97]. Patients with normal enzyme activity (approximately 88 % of the population) may receive an azathioprine dose of up to 1.5-2.5 mg/kg BW/day [183,184]. Bone marrow toxicity and hepatotoxicity are the most important adverse effects.…”
Section: Immunosuppressantsmentioning
confidence: 99%
See 1 more Smart Citation
“…Efficacy and toxicity of azathioprine are associated with the activity of the enzyme thiopurine methyltransferase [97]. Patients with normal enzyme activity (approximately 88 % of the population) may receive an azathioprine dose of up to 1.5-2.5 mg/kg BW/day [183,184]. Bone marrow toxicity and hepatotoxicity are the most important adverse effects.…”
Section: Immunosuppressantsmentioning
confidence: 99%
“…To date, the efficacy of mycophenolate mofetil has been reported in only one case of dyshidrotic eczema [185]. Methotrexate has been reported in case series of patients with recalcitrant hand eczemas [183,186]. Good results have been obtained with initial doses between 5 and 20 mg per week after 1-2 months of therapy.…”
Section: Immunosuppressantsmentioning
confidence: 99%
“…Über die Wirksamkeit von Mycophenolatmofetil wurde bislang nur in einem Fall mit dyshidrotischem Ekzem berichtet [185]. Methotrexat wurde in Fallserien von Patienten mit therapierefraktären Handekzemen berichtet [183,186]. Gute Ergebnisse wurden mit Anfangsdosen zwischen 5 und 20 mg wöchentlich nach 1-2 Monaten Therapie erzielt.…”
Section: Immunsuppressivaunclassified
“…Patienten mit normaler Enzymaktivität (ca. 88 % der Bevölkerung) können eine Azathioprin-Dosis von bis zu 1,5-2,5 mg/kg KG/Tag erhalten [183,184]. Knochenmark-und Hepatotoxizität sind die wichtigsten Nebenwirkungen.…”
Section: Immunsuppressivaunclassified