Treatment of Chromomycosis With 5‐fluorocytosine

Lopes, Cid Ferreira; Cisalpino, E. O.; Alvarenga, R. J.; Armond, S.; Pôrto, Robson V.; Maia, F. A.; Peixoto, Yeddo

doi:10.1111/j.1365-4362.1971.tb01695.x

Cited by 26 publications

(5 citation statements)

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“…Similarly, in vitro and in vivo studies with 5-fluorocytosine (5-FC) in cladosporiosis are nonexistent. However, 5-FC has been reported to cause marked regression in several cases of chromoblastomycosis (5,7,9,13). In view of the similarities between C. trichoides and fungi causing chromoblastomycosis, together with the good cerebrospinal fluid penetration of 5-FC (2), there appeared to be good reason to evaluate this drug in the therapy of cladosporiosis.…”

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confidence: 99%

Experimental Therapy of Cladosporiosis and Sporotrichosis with 5-Fluorocytosine

Block

Jennings

Bennett

1973

Antimicrob Agents Chemother

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Cladosporium trichoides and Sporothrix schenckii are fungi known to be pathogenic for man. No effective chemotherapy is available for cladosporiosis, and systemic sporotrichosis can be very resistant to antifungal chemotherapy. Experimental infections of mice with these fungi resembled their respective infections in man and provided a model for evaluating a new antifungal agent, 5-fluorocytosine (5-FC). Our results with four isolates of C. trichoides demonstrated a statistically significant dose-related therapeutic effect with 5-FC. Mortality was significantly reduced in all treatment groups, and survivors showed no clinical sign of disease despite positive brain cultures. Results with a single isolate of S. schenckii were less encouraging. Fatality rate was significantly decreased in all treatment groups, but no trend was noted with increasing 5-FC dosage. Survivors manifested the signs of active disease, and all liver and spleen cultures were positive for S. schenckii. These results indicated that (i) 5-FC may be the first drug useful in the treatment of cladosporiosis, and (ii) 5-FC may have only limited therapeutic benefit in systemic sporotrichosis.

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confidence: 99%

Experimental Therapy of Cladosporiosis and Sporotrichosis with 5-Fluorocytosine

Block

Jennings

Bennett

1973

Antimicrob Agents Chemother

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“…Intralesional amphotericin B has enjoyed most favour but appears to be palliative rather than curative in lesions of this size (Whiting 1967). Encouraging success has been reported with 5-fluorocytosine (Lopes 1971). The organism in this patient is sensitive to the drug and a trial of this therapy has been commenced.…”

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confidence: 88%

Practolol-Induced Drug Eruption

Assem¹,

Banks

1973

Proceedings of the Royal Society of Medicine

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“…More recently, thiabendazole has achieved some favour but improvement without cure has been a common finding, severe side-effects in occur some cases (Bayles, 1971). A number of favourable reports on the use of 5-FC in chromoblastomycosis have recently been published (Lopes, 1969(Lopes, , 1970(Lopes, , 1971Itani, 1970). The largest trial involved ten patients, all of whom were cleared of the infection (Magalhaes & Meyer, 1970).…”

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confidence: 99%