Treatment of chromoblastomycosis with a combination of debulking surgery, intralesional amphotericin B, and oral terbinafine

Cutaneous Mucormycosis of the Eyelid Treated With Subcutaneous Liposomal Amphotericin B Injections

“…10 Similarly, intralesional and subcutaneous injection of amphotericin B in an off-label application have been successfully used in the treatment of cutaneous leishmaniasis and chromoblastomycosis infections with minimal to no injection-site complications. 11–14…”

Amphotericin-B in dermatology

“… Anecdotal case reports of encouraging results with AmB have been described in cutaneous fusariosis,[ 26 ] protothecosis,[ 27 ] primary cutaneous aspergilloisis,[ 28 ] cutaneous histoplasmosis,[ 29 ] chromoblastomycosis (oral[ 30 ] and intralesional[ 31 ]), and blastomycosis. [ 32 ] Successful treatment of nondermatophytic molds such as fusarium and other species which do not respond to standard onychomycosis treatment has shown success in a small series of eight patients with topical AmB.…”

“…Anecdotal case reports of encouraging results with AmB have been described in cutaneous fusariosis,[ 26 ] protothecosis,[ 27 ] primary cutaneous aspergilloisis,[ 28 ] cutaneous histoplasmosis,[ 29 ] chromoblastomycosis (oral[ 30 ] and intralesional[ 31 ]), and blastomycosis. [ 32 ]…”

Traumatic Orbital Roof Fracture With Superior Rectus Entrapment in a Pediatric Patient

“…10 Similarly, intralesional and subcutaneous injection of amphotericin B in an off-label application have been successfully used in the treatment of cutaneous leishmaniasis and chromoblastomycosis infections with minimal to no injection-site complications. [11][12][13][14] In this series, the patients were injected with 1 ml of LAmB (3.5 mg/ml) per injection. This formulation was chosen due to institutional availability.…”

“…To the authors' knowledge, the local injection of amphotericin B for other cutaneous disorders has not led to notable systemic accumulation or adverse events. [11][12][13][14] This is in contrast to the intravenous administration of the drug, which can have nephrotoxic as well as other side effects. It is likely that systemic absorption of cutaneously injected drug is low because of the low volume and concentration of each local injection.…”