Treatment of Choroidal Neovascularization Due to Angioid Streaks

Abstract

Intravitreal vascular endothelial growth factor inhibitors are currently the most effective treatment of CNV due to angioid streaks.

Intravitreal aflibercept for choroidal neovascularisation in angioid streaks

“…2 This approach, in which treatment is withheld unless there is CNV activity, has been the most widely adopted in this setting. 3,4 Treat and extend (T&E) is a treatment modality that aims to treat the CNV proactively, in order to find an optimal treatment interval, and has been more commonly used in the context of neovascular age-related macular degeneration (nAMD). While we find the T&E modality to be an interesting approach for AS-associated CNV, we agree with previous reports that the CNV in this context is closer to myopia-related CNV than nAMD-related CNV, and therefore may require fewer injections.…”

Long-Term Follow-Up of Choroidal Neovascularization due to Angioid Streaks with pro re nata Intravitreal Anti-VEGF Treatment

“…Currently, intravitreal vascular endothelial growth factor (VEGF) inhibitors are the most effective therapy for CNV due to AS; treatment with bevacizumab or ranibizumab was found to lead to stabilization or an increase in best corrected visual acuity (BCVA) in the majority of patients [23] . Encouraging anatomical results were achieved in all studies except one [24] , and these studies report a reduction or at least a stabilization of the central retinal thickness measured by optical coherence tomography (OCT) [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] .…”

Drastic effect of ranibizumab on choroidal neovascularization in idiopathic angioid streaks

“…Furthermore, Karacorlu et al (8) reported beneficial effects of PDT on CNV, though several other studies have reported no positive effect of PDT in CNV patients. It has been generally agreed that following PDT treatment the greatest linear CNV diameter, which indicates lesion size, is increased at the time of final examination when compared to initial lesion diameter (5) , indicating disease progression despite PDT. Anti-VEGF treatment of CNV due to angioid streaks was first reported by Teixeira et al, (9) who reported increased BCVA and decreased disease activity following bevacizumab injection.…”

“…A previous study has shown that 5% of all CNV lesions are related to angioid streaks (4) . CNV is reported to occur in up to 86% of patients with angioid streaks, resulting in serious visual disability (5) . Laser photocoagulation, photodynamic therapy, surgical excision, and intravitreal injections of anti-VEGF agents have been used to treat CNV lesions associated with angioid streaks.…”