Treatment of Cholelithiasis in Children with Sickle Cell Disease

Hendricks-Ferguson, Verna L.; Nelson, Martha A.

doi:10.1016/s0001-2092(06)60979-4

Cited by 26 publications

(25 citation statements)

References 14 publications

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“…Hendricks-Ferguson V, reported that a great number of surgeons now remove asymptomatic stones in SS disease patients 40 .…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of cholelithiasis is high in patients with HbSS/SCA and increases progressively with age, affecting 15% of children with SCA younger than 10 years of age and more than 80% of those older than 30 years 9,10 . Other studies reported a range of 6% in patients under 15 years and increases progressively with age, affecting 50% of young adults 11,12 .…”

Section: Introductionmentioning

confidence: 99%

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Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Attalla¹,

Karrar²,

Ibnouf³

et al. 2013

Af Hlth Sci

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Background: SCA causes chronic haemolysis which is a risk factor for cholelithiasis. Objective: To determine the prevalence and outcome of children with SCA complicated with gallstones treated at the sickle cell clinic at the children emergency hospital Khartoum state. Methods: 261 patients age 4 months to 16 years were studied. AUS examination was carried out. The 30 patients in whom gall stones were detected followed prospectively from June 1996 to September 2009 when a second AUS examination was obtained.Results: Gall stones occurred in 30 patients of whom four were lost to follow up in the first year. The overall prevalence of cholelithiasis was 11.5% and it increased with age. The youngest patient with cholelithiasis was 2 1/2 years old. Haematological variables, bilirubin and sex did not identify a subgroup of patients at higher risk for gallstones. All the patients were asymptomatic at the time of diagnosis. One patient developed symptoms 3years after the diagnosis and he was submitted to surgery. The 25 remaining asymptomatic patients were followed up for 13 years and none of them presented complications related to cholelithiasis during this period. Conclusion: The prevalence of cholelithiasis in Sudanese children and adolescents with SCA was significant. The large majority patients remained asymptomatic over a long period. African Health Sciences 2013; 13(1): 154 -159 http://dx.doi.org/10.4314/ahs.v13i1.21

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“…Hendricks-Ferguson V, reported that a great number of surgeons now remove asymptomatic stones in SS disease patients 40 .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Attalla¹,

Karrar²,

Ibnouf³

et al. 2013

Af Hlth Sci

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“…The development of gallstones is age dependent and related to chronic hemolysis, which causes increased bilirubin excretion and subsequently increased formation of pigment gallstones [12]. Cholelithiasis affects 15% of patients with sickle cell disease (SCD) younger than 10 years of age and >80% of those older than 30 years [4]. Among children with spherocytosis, >40% develop detectable gallstones between 10 and 30 years of age and 6-16% undergo cholecystectomy for symptomatic gallbladder disease [16].…”

mentioning

confidence: 99%

Laparoscopic cholecystectomy in children with chronic hemolytic anemia

et al. 2005

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“…Deshalb kann bei diesen Eingriffen prophylaktisch eine simultane Cholezystektomie durchgeführt werden [10,67]. Etwa 50% der Patienten mit Sichelzellanämie entwickeln Pigmentsteine [31]. Während früher aufgrund einer deutlich erhöhten perioperativen Morbidität und Mortalität wegen vasookklusiver Krisen die Indikation zur Cholezystektomie bei asymptomatischen Sichelzellanämie-Patienten restriktiv gestellt wurde, wird diese heute nach Einführung der laparoskopischen Operationstechnik großzügiger gefasst [31][32][33].…”

Section: Asymptomatische Cholezystolithiasisunclassified

“…Etwa 50% der Patienten mit Sichelzellanämie entwickeln Pigmentsteine [31]. Während früher aufgrund einer deutlich erhöhten perioperativen Morbidität und Mortalität wegen vasookklusiver Krisen die Indikation zur Cholezystektomie bei asymptomatischen Sichelzellanämie-Patienten restriktiv gestellt wurde, wird diese heute nach Einführung der laparoskopischen Operationstechnik großzügiger gefasst [31][32][33]. Patienten mit Diabetes mellitus profitieren nicht von einer prophylaktischen Cholezystektomie [10,34,67].…”

Section: Asymptomatische Cholezystolithiasisunclassified

Cholezystolithiasis – ein Wandel im interdisziplinären Vorgehen?

2006

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Cholecystolithiasis has an enormous clinical and socioeconomic impact due to its high prevalence and the risk to develop severe complications. 80% of persons with gallstones are asymptomatic at the time of diagnosis. After a first episode of biliary symptoms, about 70% of patients will experience recurrent biliary symptoms within 2 years, and 1-2% per year will develop biliary complications. The diagnosis of gallstone disease is made on the basis of the patient's history, a physical examination, an abdominal ultrasound, and laboratory tests to exclude complications such as cholecystitis, cholangitis, choledocholithiasis, and pancreatitis. Asymptomatic cholecystolithiasis is usually not treated. Exceptions are a porcelain gallbladder, simultaneous gallbladder polyps ‡ 10 mm, and gallstones > 3 cm due to the enhanced risk to develop gallbladder carcinoma. In addition, prophylactic cholecystectomy may be considered in asymptomatic patients undergoing heart transplantation or surgery for morbid obesity. Laparoscopic cholecystectomy represents the first-line treatment of symptomatic cholecystolithiasis. Nonsurgical treatment with ursodeoxycholic acid should only be considered in patients with small (£ 5(-10) mm), mildly symptomatic gallbladder stones in a functioning gallbladder when surgery is refused by the patient, surgical risk is high, or surgery is impossible. Extracorporeal shock wave lithotripsy of gallbladder stones is not recommended any more considering recurrence rates of 50-80% after 10 years.

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Treatment of Cholelithiasis in Children with Sickle Cell Disease

Cited by 26 publications

References 14 publications

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Laparoscopic cholecystectomy in children with chronic hemolytic anemia

Cholezystolithiasis – ein Wandel im interdisziplinären Vorgehen?

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