Treatment of Cheyne‐Stokes Respiration Reduces Arrhythmic Events in Chronic Heart Failure

Bitter, Thomas; Gutleben, Klaus-Jürgen; Nölker, Georg; Westerheide, Nina; Prinz, Christian; Dimitriadis, Zisis; Horstkotte, Dieter; Vogt, Jürgen; Oldenburg, Olaf

doi:10.1111/jce.12197

Cited by 45 publications

(28 citation statements)

References 43 publications

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“…118 Several short-term randomized controlled trials have evaluated the effects of ASV on CSA severity and LV function ( Table 2). Although these studies show that ASV abolishes CSA, its effects on LVEF are inconsistent.…”

Section: Csamentioning

confidence: 99%

Heart Failure and Sleep Apnea

Lyons

Bradley

2015

Canadian Journal of Cardiology

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Section: Csamentioning

confidence: 99%

Heart Failure and Sleep Apnea

Lyons

Bradley

2015

Canadian Journal of Cardiology

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“…2) [90]. Subsequently, observational data showed that treatment of CSA using adaptive servo-ventilation (ASV) therapy was associated with a decrease of malignant arrhythmic events [91].…”

Section: Premature Atrial or Ventricular Complexesmentioning

confidence: 99%

Sleep apnoea and the heart

Lévy

Ryan

Oldenburg

et al. 2013

European Respiratory Review

108

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Sleep apnoea is associated with significant daytime functioning impairment and marked cardiovascular morbidities, leading to a significant increase in mortality. Sympathetic activation, oxidative stress and systemic inflammation have been shown to be the main intermediary mechanisms associated with sleep apnoea and intermittent hypoxia. There are now convincing data regarding the association between hypertension, arrhythmias, coronary heart disease, heart failure, increased cardiovascular mortality and sleep apnoea. This has been evidenced in sleep apnoea patients and is supported by experimental data obtained in intermittent hypoxia. Whether treating sleep apnoea enables chronic cardiovascular consequences to be reversed is not fully established as regard coronary heart disease, arrhythmias and heart failure. In this late condition, complex bidirectional relationships occur, with obstructive sleep apnoea being a risk factor for heart failure whilst central sleep apnoea mainly appears as a consequence of heart failure. It remains to be established in adequately designed studies, i.e. large randomised controlled trials, whether treating sleep apnoea can improve heart failure morbidity and mortality. @ERSpublications Sleep apnoea is associated with arrhythmias, coronary disease and heart failure through intermittent hypoxia http://ow.ly/ne19T

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“…23 Finally, a study by Bitter et al could not be included in the meta-analysis because no standard deviations were provided, but demonstrated a small increase in LVEF with ASV. 6 (see Figure S1) apnea-Hypopnea index: Twenty-six studies 5,[29][30][31][32] reported data on the effects of ASV on AHI and were consistent in showing that ASV improves AHI over baseline. Meta-analyses indicate that ASV decreases AHI by 30 events/h (95% CI: −27 to −34 events/h) over baseline.…”

Section: -32mentioning

confidence: 80%

“…Finally, studies by Bitter et al, Cowie et al and Morgenthaler et al could not be included in the meta-analysis because they did not provide standard deviation, but demonstrated a normalization of AHI with ASV. 2,6,28 (see supplemental material, Figure S2) MortaLity (cardiac deatH): Four studies 2,12-14 reported data on mortality in CHF patients using ASV compared to standard care. Cowie et al…”

Section: -32mentioning

confidence: 99%

Updated Adaptive Servo-Ventilation Recommendations for the 2012 AASM Guideline: “The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses”

Bista

et al. 2016

Journal of Clinical Sleep Medicine

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An update of the 2012 systematic review and meta-analyses were performed and a modified-GRADE approach was used to update the recommendation for the use of adaptive servo-ventilation (ASV) for the treatment of central sleep apnea syndrome (CSAS) related to congestive heart failure (CHF). Metaanalyses demonstrated an improvement in LVEF and a normalization of AHI in all patients. Analyses also demonstrated an increased risk of cardiac mortality in patients with an LVEF of ≤ 45% and moderate or severe CSA predominant sleep-disordered breathing. These data support a Standard level recommendation against the use of ASV to treat CHF-associated CSAS in patients with an LVEF of ≤ 45% and moderate or severe CSAS, and an Option level recommendation for the use of ASV in the treatment CHF-associated CSAS in patients with an LVEF > 45% or mild CHF-related CSAS. The application of these recommendations is limited to the target patient populations; the ultimate judgment regarding propriety of any specific care must be made by the clinician.

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Treatment of Cheyne‐Stokes Respiration Reduces Arrhythmic Events in Chronic Heart Failure

Abstract: This study demonstrates a decrease of appropriate defibrillator therapies by ASV treated CSR in patients with CHF and ICD. A reduced exposure to hyperventilation, hypoxia, and improvement in indices of CHF severity and neurohumoral disarrangements are potential causative mechanisms.

Cited by 45 publications

References 43 publications

Heart Failure and Sleep Apnea

Heart Failure and Sleep Apnea

Sleep apnoea and the heart

Updated Adaptive Servo-Ventilation Recommendations for the 2012 AASM Guideline: “The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses”

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