Treatment of cerebral cysticercosis with albendazole in elevated dosages

Rocha, Marco Antônio; Santos, Juliana Machado Santiago dos; Gomes, Elisa Conci de Souza; Rocha, Cristiane Franklin; Carvalho, Gervásio Teles Cardoso de; Costa, Bruno Silva

doi:10.1590/s0004-282x2008000100032

Cited by 8 publications

(7 citation statements)

References 6 publications

(16 reference statements)

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“…Other non-responsive NC cases have been previously published (Table 1, [9-12]) but including patients that differ in the clinical picture, the parasite localization and cysticidal doses used. Even though the causes of the parasite's persistence, despite the ABZ treatment, are still unknown, multiple host and parasite factors may be involved.…”

Section: Resultsmentioning

confidence: 99%

Subarachnoidal Neurocysticercosis non-responsive to cysticidal drugs: a case series

et al. 2010

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BackgroundNeurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to treatment.Case PresentationThe clinical and radiological pictures of six Mexican patients non-respondent to cysticidal treatment are presented.ConclusionsThe possible factors involved in the cysticidal non-response are discussed and hints are provided of potentially useful changes to therapeutic protocols.

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Section: Resultsmentioning

confidence: 99%

Subarachnoidal Neurocysticercosis non-responsive to cysticidal drugs: a case series

et al. 2010

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“…No caso relatado, tendo-se em vista a magnitude da lesão intracraniana e a sintomatologia de compressão do parênquima cerebral pelo cisto gigante, com instabilidade importante do quadro neurológico, a intervenção cirúrgica é a conduta terapêutica mais recomendada 13 . A NCC é uma doença relativamente prevalente no nosso meio.…”

Section: Imagem Em Medicinaunclassified

“…Colli ainda cita que o melhor tratamento para a forma tumoral da NCC é a exérese cirúrgica por acesso direto 12 . No caso relatado optou-se por tratamento cirúrgico da lesão 13 . Essa cirurgia visa a exérese dos cistos por abordagem direta, ou pelo menos à sua ressecção parcial, e é realizada com relativa facilidade quando o cisto gigante está …”

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Neurocisticercose gigante: diagnóstico e tratamento

Brandão¹,

Nunes²,

Filho³

et al. 2010

Rev. Assoc. Med. Bras.

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“…Nevertheless, these drugs are not effective in all NC patients, particularly in those cases where cysts are established in the ventricles or in the subarachnoid space of the base [5][6][7][8]. Some evidence that the immunity-mediated inflammation observed during NC infection is involved in treatment responsiveness has been recently published [9].…”

Section: Introductionmentioning

confidence: 99%

Treatment-Resistant Human Extraparenchymal Neurocysticercosis: An Immune-Inflammatory Approach to Cysticidal Treatment Outcome

Arce-Sillas

Cárdenas

Álvarez-Luquín

et al. 2018

Neuroimmunomodulation

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Objective: The aim of this study is to analyze the immune-endocrine profile in neurocysticercosis (NC) patients resistant to cysticidal treatment. Methods: The inflammatory and regulatory responses of 8 resistant NC patients with extraparenchymal parasites and 5 healthy controls were evaluated through flow cytometry. Serum interleukin levels were measured by ELISA and catecholamines levels by high performance liquid chromatography. Results: Higher percentages of Tr1, CD4+CD25+FOXP3+CD127– and CD4+CD45RO+FOXP3^HI were found in NC patients compared with healthy controls, but no difference was found in catecholamine levels. Antigen-specific proliferative immune response was observed in NC patients. Neither anti-inflammatory nor pro-inflammatory cytokines showed differences between patients and controls, but IL-6 levels were lower in treatment-resistant NC patients. In addition, TGFβ showed a significant negative correlation with dopamine. Conclusions: Altogether, these results may point to a modulation of the neuroinflammation in these patients that could indirectly favor cysticercal survival in CNS microenvironment.

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Treatment of cerebral cysticercosis with albendazole in elevated dosages

Cited by 8 publications

References 6 publications

Subarachnoidal Neurocysticercosis non-responsive to cysticidal drugs: a case series

Subarachnoidal Neurocysticercosis non-responsive to cysticidal drugs: a case series

Neurocisticercose gigante: diagnóstico e tratamento

Treatment-Resistant Human Extraparenchymal Neurocysticercosis: An Immune-Inflammatory Approach to Cysticidal Treatment Outcome

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