Treatment of central giant cell granuloma of the jaw with calcitonin

Lange, Jan de; Rosenberg, Antoine J.W.P.; Akker, Hans P. van den; Koole, R.; Wirds, J.J.; Berg, Henk van den

doi:10.1016/s0901-5027(99)80086-1

Cited by 84 publications

(110 citation statements)

References 21 publications

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“…Recently, successful calcitonin treatment for GCRG of the jaw has also been reported. 8) Procedures other than surgical removal were not indicated in our case.…”

Section: Discussionmentioning

confidence: 74%

Giant Cell Reparative Granuloma of the Temporal Bone: Neuroradiological and Immunohistochemical Findings. Case Report.

Yoshimura

Onda

Tanaka

et al. 2002

Neurol. Med. Chir.(Tokyo)

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A 38-year-old man presented with a giant cell reparative granuloma (GCRG) of the left temporal bone. Computed tomography showed a osteolytic middle cranial mass lesion. Magnetic resonance (MR) imaging showed the lesion as low intensity with heterogeneous enhancement by gadolinium on the T 1 -weighted images, and extremely low intensity on the T 2 -weighted images. Angiography showed the lesion as highly vascular and fed by branches of the left external carotid artery. After preoperative embolization, gross total removal of the tumor was performed. The postoperative course was uneventful and no evidence of recurrence has been found for more than 4 years. Histological examination revealed GCRG with multinucleated giant cells in the fibrous background, abundant collagen bundles, hemosiderin deposits, and trabeculae of reactive bone. Some of the mononuclear stromal cells and almost all of the giant cells were positive for CD68, suggesting histiocytic differentiation. These histological features reflect the marked decrease in signal intensity on T 2 -weighted MR images.

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“…Recently, successful calcitonin treatment for GCRG of the jaw has also been reported. 8) Procedures other than surgical removal were not indicated in our case.…”

Section: Discussionmentioning

confidence: 74%

Giant Cell Reparative Granuloma of the Temporal Bone: Neuroradiological and Immunohistochemical Findings. Case Report.

Yoshimura

Onda

Tanaka

et al. 2002

Neurol. Med. Chir.(Tokyo)

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“…18 The biochemical bone markers, such as serum calcium, phosphorus and alkaline phosphatase, have been found within the normal ranges for the respective age. 9,19,20 This was also so in our case.…”

Section: -13mentioning

confidence: 88%

Aggressive behaviour of cherubism in a teenager: 4-years of clinical follow-up associated with radiographic and histological features

Gomes¹,

Destro²,

Banzi³

et al. 2005

Dentomaxillofacial Radiology

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Cherubism is a rare hereditary fibro-osseous childhood disease characterized by bone degradation and fibrous tissue replacement at the angles of the mandible and at the tuberosity areas of the maxilla that leads to prominence of the lower face and an appearance reminiscent of the cherub's portrayal in Renaissance art. This disease has an autosomal dominant hereditary characteristic. The purpose of this report is to analyse laboratory tests, clinicopathological and radiographic features of cherubism and its intraoral manifestations in a patient during 4-years of follow-up, correlating the features observed in this case with those of the literature. Also discussed is the atypical and aggressive behaviour of this case during puberty. No known cases of cherubism involving her biological father, mother, two younger brothers or other relatives were found during the review of the patient's family medical history. The menarche of this female patient occurred when she was 11 years old.At extraoral evaluation, the expression and colour of the face were normal and the eyes did not reveal any abnormalities. At intraoral clinical examination, the absence of the lower right first and second molars and the lower left second molar with bilateral eversion of the vestibule were observed. The mucosa of the right side showed a rigid consistency, whiteness and marks made by the occlusal surfaces of antagonist teeth, but the left side displayed a normal aspect.For radiological study, lateral and panoramic radiographs and computed tomography (CT) were obtained. The images showed bilateral multilocular lesions located in the body, angle, ramus and coronoid process of mandible, not affecting the condyles. In the right side, with the absence of the lower first molar, the second molar was found dislocated to the base of the mandibular bone and the third molar was directed towards the lingual cortex and mandibular angle. Their roots were incompletely formed. In the left side, the lower second molar was located below the first molar, which presented severe resorption of the distal root. The lower third molar was floating within the lesion. The maxilla showed absence of the disease and absence of the first left and right molars (Figure 2)

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“…12 The nasal spray has the advantage of avoiding daily injections, and the side effects are considerably less in comparison with subcutaneous injections. 16 However, the disadvantages of nasal spray include the low absorption of calcitonin through the nasal mucosa, which is variable and ranges between 20% and 100% when compared to injections. 10 Thus, a daily dose of 400 IU calcitonin nasal spray would be equivalent to as low as 80 IU and as high as 400 IU of the injected calcitonin.…”

Section: Discussionmentioning

confidence: 99%

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

Fardisi

Zamiri

Amanpour

et al. 2016

International Journal of Oral and Maxillofacial Surgery

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Treatment of central giant cell granuloma of the jaw with calcitonin

Cited by 84 publications

References 21 publications

Giant Cell Reparative Granuloma of the Temporal Bone: Neuroradiological and Immunohistochemical Findings. Case Report.

Giant Cell Reparative Granuloma of the Temporal Bone: Neuroradiological and Immunohistochemical Findings. Case Report.

Aggressive behaviour of cherubism in a teenager: 4-years of clinical follow-up associated with radiographic and histological features

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

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