Новосибирский государственный медицинский университет, Российская Федерация A clinical study involved 90 patients with chronic osteomyelitis. Patients were divided into two groups. In group I, 60 patients underwent sequestrectomy and plastic surgery of the sequestral cavity with finely granulated titanium nickelide. In group II, 30 patients after sequestrectomy, the bone cavity was filled in the traditional way (hemoplasty). Both in the early postoperative period and the long follow-up period, the clinical and radiological effects of the proposed methodology for treating residual bone cavities were confirmed. When using titanium nickelide implants, the formation of biocomposite is observed in patients, which ensures the preservation of bone strength. This prevents the occurrence of pathological fractures. Titanium nicelide is characterized by mechanical strength, has osteoconductive properties and allows sufficient filling of cavities with complex anatomical structure. Also, preservation of congruence of composite with bone tissue during bone growth (in case of treatment of children) is noted.