Treatment of catatonia with intravenous biperidene

Franz, Michael; Gallhofer, Bernd; Kanzow, W. T. H.

doi:10.1192/bjp.164.6.847b

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…There is anecdotal evidence from case-reports on the use of various other pharmacological agents, such as bromocriptine ( 111 ) and biperiden ( 112 ). Based on the GABA-hypothesis of catatonia, and the GABA-related working mechanism of several anti-convulsive mood stabilizers, these drugs have been proposed as a possible treatment option for the treatment of catatonia in bipolar patients.…”

Section: Treatment Of Catatoniamentioning

confidence: 99%

A Clinical Review of the Treatment of Catatonia

Sienaert¹,

Dhossche²,

Vancampfort³

et al. 2014

Front. Psychiatry

234

312

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Catatonia is a severe motor syndrome with an estimated prevalence among psychiatric inpatients of about 10%. At times, it is life-threatening especially in its malignant form when complicated by fever and autonomic disturbances. Catatonia can accompany many different psychiatric illnesses and somatic diseases. In order to recognize the catatonic syndrome, apart from thorough and repeated observation, a clinical examination is needed. A screening instrument, such as the Bush-Francis Catatonia Rating Scale, can guide the clinician through the neuropsychiatric examination. Although severe and life-threatening, catatonia has a good prognosis. Research on the treatment of catatonia is scarce, but there is overwhelming clinical evidence of the efficacy of benzodiazepines, such as lorazepam, and electroconvulsive therapy.

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Section: Treatment Of Catatoniamentioning

confidence: 99%

A Clinical Review of the Treatment of Catatonia

Sienaert¹,

Dhossche²,

Vancampfort³

et al. 2014

Front. Psychiatry

234

312

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“…45 Due to its favorable pharmacokinetic properties, 46 lorazepam is widely recommended as the drug of choice in catatonia but other benzodiazepines or other agents may also be effective. [46][47][48][49][50] However, the efficacy of lorazepam in treating acute catatonic symptoms in schizophrenia seems to be limited compared with catatonia associated with mood or other disorders. 51,52 According to a recent review, only 20%-30% of patients with catatonic symptoms in the context of schizophrenia respond to benzodiazepines.…”

Section: Treatment Response and The Heterogeneity Of Catatoniamentioning

confidence: 99%

The Catatonia Conundrum: Evidence of Psychomotor Phenomena as a Symptom Dimension in Psychotic Disorders

Ungvári

Caroff

Gerevich

2009

Schizophrenia Bulletin

111

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To provide a rational basis for reconceptualizing catatonia in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition), we briefly review historical sources, the psychopathology of catatonia, and the relevance of catatonic schizophrenia in contemporary practice and research. In contrast to Kahlbaum, Kraepelin and others (Jaspers, Kleist, and Schneider) recognized the prevalence of motor symptoms in diverse psychiatric disorders but concluded that the unique pattern and persistence of certain psychomotor phenomena defined a "catatonic" subtype of schizophrenia, based on intensive long-term studies. The enduring controversy and confusion that ensued underscores the fact that the main problem with catatonia is not just its place in Diagnostic and Statistical Manual of Mental Disorders but rather its lack of conceptual clarity. There still are no accepted principles on what makes a symptom catatonic and no consensus on which signs and symptoms constitute a catatonic syndrome. The resulting heterogeneity is reflected in treatment studies that show that stuporous catatonia in any acute disorder responds to benzodiazepines or electroconvulsive therapy, whereas catatonia in the context of chronic schizophrenia is phenomenologically different and less responsive to either modality. Although psychomotor phenomena are an intrinsic feature of acute and especially chronic schizophrenia, they are insufficiently recognized in practice and research but may have significant implications for treatment outcome and neurobiological studies. While devising a separate category of catatonia as a nonspecific syndrome has heuristic value, it may be equally if not more important to re-examine the psychopathological basis for defining psychomotor symptoms as catatonic and to re-establish psychomotor phenomena as a fundamental symptom dimension or criterion for both psychotic and mood disorders.

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“…These intervals were chosen based on the plasma half-life of biperiden 14 and the effect of single-dose injections of these agents reported in the literature. [15][16][17] Side effects of both treatments were recorded.…”

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confidence: 99%