Treatment of Carcinoma Op the Tongue

Nimotuzumab in Treatment of Infiltrating Squamous Cell Carcinoma of Tongue

“…Patient was staged as T3, N2, M0. Excision of mass on the tongue was done and biopsy sent for histopathological examination which revealed infiltrating squamous cell carcinoma [3].…”

“…The 5-year survival rates for patients in Stages III and IV are 30% -50%, with lymph node metastasis decreasing the survival rate 15% -30%. Treatment failure often occurs in the cervical lymph nodes, even for patients with an N0 neck [3]. To better evaluate prognosis and outcome, many studies have looked at the expression of various growth factors and tumor markers.…”

“…It terminates fatally in 75 to 90 percent of cases, according to Warren, Butlin and Meller [2]. In frequency, Jessett [2] places it second only to carcinoma of the cervix, while Jacobsen [3] gives it third place. India stands distinctly claiming that it is the "oral cancer capital of the world" and is the second most frequent tumour among the oral tumors [4].…”

“…The general beliefs are that superficial lesions are treated with single-modality therapy (e.g., radiation or surgery) and that large lesions are treated with multiple modalities (e.g., combined surgery and radiation). Additionally, cervical nodes are treated with either surgery or radiation therapy, and survival increases if microscopically positive nodes are present [3]. The therapeutic decision must take into consideration the patient's age, lifestyle, and willingness to participate in the therapeutic regimen.…”

“…Treatment failure often occurs in the cervical lymph nodes, even for patients with an N0 neck. Targeted therapies are the next revolution in the management of head and neck cancers (HNSCC) [3]. Almost 90% of the tumours have over-expressed EGFR receptors and numerous studies have proven a poorer prognosis in such patients [6].…”