Treatment of Cancer Pain with Noninvasive Brain Stimulation

Silva, Gisele Rodrigues da; Miksad, Rebecca A.; Freedman, Steven D.; Pascual‐Leone, Álvaro; Jain, Sanjay; Gomes, Daniela Laranja; Amâncio, Edson José; Boggio, Paulo S.; Correa, Carlos; Fregni, Felipe

doi:10.1016/j.jpainsymman.2007.06.002

Cited by 32 publications

(31 citation statements)

References 15 publications

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“…A second study from this group showed that anodal tDCS over M1 also produced decreases in pain intensity in patients with fibromyalgia that were maintained for up to three weeks [19]. Finally, Silva and colleagues published a case report describing how anodal tDCS over M1 may induce analgesic effects in cancer pain [20]. The patient in this study had severe pain for several months and responded well to active, but not sham, anodal tDCS over M1.…”

Section: Introductionmentioning

confidence: 87%

Pain Reduction in Myofascial Pain Syndrome by Anodal Transcranial Direct Current Stimulation Combined With Standard Treatment

Sakrajai

Janyacharoen

Jensen

et al. 2014

The Clinical Journal of Pain

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Background Myofascial pain syndrome (MPS) in the shoulder is among the most prevalent pain problems in the middle-aged population worldwide. Evidence suggests that peripheral and central sensitization may play an important role in the development and maintenance of shoulder MPS. Given previous research supporting the potential efficacy of anodal transcranial direct current stimulation (tDCS) for modulating pain-related brain activity in individuals with refractory central pain, we hypothesized that anodal tDCS when applied over the primary motor cortex (M1) combined with standard treatment will be more effective for reducing pain in patients with MPS than standard treatment alone. Method Study participants were randomized to receive either (1) standard treatment with 5-consecutive days of 1 mA anodal tDCS over M1 for 20 min or (2) standard treatment plus sham tDCS. Measures of pain intensity, shoulder passive range of motion, analgesic medication use, and self-reported physical functioning were administered before treatment and again at post-treatment and 1-, 2-, 3-and 4-week follow-up. Results Thirty-one patients with MPS were enrolled. Participants assigned to the active tDCS condition reported significantly more pre- to post-treatment reductions in pain intensity that were maintained at 1-week post-treatment, and significant improvement in shoulder adduction PROM at 1-week follow-up than participants assigned to the sham tDCS condition. Conclusion 5 consecutive days of anodal tDCS over M1 combined with standard treatment appears to reduce pain intensity, and may improve PROM, faster than standard treatment alone. Further tests of the efficacy and duration of effects of tDCS in the treatment of MPS are warranted.

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Section: Introductionmentioning

confidence: 87%

Pain Reduction in Myofascial Pain Syndrome by Anodal Transcranial Direct Current Stimulation Combined With Standard Treatment

Sakrajai

Janyacharoen

Jensen

et al. 2014

The Clinical Journal of Pain

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“…In 2009, one report confirmed tDCS to be an alternative therapy for pancreatic cancer pain control [11]. The report also claimed that tDCS worked by stimulating the primary motor cortex area (M1) and the contralateral supraorbital region, and no adverse effects were associated with this treatment.…”

Section: Introductionmentioning

confidence: 99%

Numeric Investigation of Brain Tumor Influence on the Current Distributions During Transcranial Direct Current Stimulation

Song

Wen

Ahfock

et al. 2016

IEEE Trans. Biomed. Eng.

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This study constructed a series of high-resolution realistic human-head models with brain tumors, and numerically investigated the influence of brain tumor's location and grade on the current distributions, under different electrode montages during tDCS. The threshold area and the peak current density were also derived and analyzed in the region of interest. The simulation result showed that it is safe to apply tDCS on the patients with brain tumors to treat their neuropsychiatric conditions and cancer pain caused by the tumor; although considerable changes of the current distributions are induced by the presence of a brain tumor. In addition, several observations on the global and local influences of tumor grade and possible edema have been made as well. These findings should be helpful for researchers and clinical doctors to treat patients with brain tumors. This study is also the first numerical study to fill in the gap of tDCS applications on the patients with brain tumors.

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“…These researchers have reported the effects of cerebral cortex control through diverse neural networks. In particular, tDCS is used as an excellent means for enhancing mood and anxiety in patients suffering from depression, and also to control chronic pain [14] in patients with traumatic spinal cord injury [15], fibromyalgia [16], and cancer [17]. There has been much research, in various fields, into the effects of applying tDCS, but most of the research into sensory functions, dealing with pain and its mechanisms, has not been verified.…”

Section: Introductionmentioning

confidence: 99%

Changes in the Sensory Function after Transcranial Direct Stimulation on Dorsolateral Prefrontal Cortex Area

Min¹

2015

Journal of the Korea Academia-Industrial cooperation Society

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Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers a low-intensity direct current to the cortical areas, thereby facilitating or inhibiting spontaneous neuronal activity. This study was designed to examine the changes in various sensory functions after tDCS. A single-center, single-blinded, randomized trial was conducted to determine the effect of a single session (August 4 to August 29) of tDCS with the current perception threshold (CPT) in 50 healthy volunteers. Nerve conduction studies (NCS) were performed in relation to the median sensory and motor nerves on the dominant hand to discriminate peripheral nerve lesions. The subjects received anodal tDCS with 1mA for 15 minutes under two different conditions, with 25 subjects in each group. The conditions were as follows: tDCS on the dorsolateral prefrontal cortex (DLPFC) and sham tDCS on DLPFC. The parameters of the CPT was recorded with a Neurometer ® at frequencies of 2000, 250 and 5 Hz in the dominant index finger to assess the tactile sense, fast pain and slow pain, respectively. In the test to measure the CPT values of the DLPFC in the anodal tDCS group, the values increased significantly in all of 250 and 5 Hz. All CPT values decreased for the sham tDCS. These results showed that DLPFC anodal tDCS can modulate the sensory perception and pain thresholds in healthy adult volunteers. This study suggests that tDCS may be a useful strategy for treating central neurogenic pain in rehabilitation medicine.

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Treatment of Cancer Pain with Noninvasive Brain Stimulation

Cited by 32 publications

References 15 publications

Pain Reduction in Myofascial Pain Syndrome by Anodal Transcranial Direct Current Stimulation Combined With Standard Treatment

Pain Reduction in Myofascial Pain Syndrome by Anodal Transcranial Direct Current Stimulation Combined With Standard Treatment

Numeric Investigation of Brain Tumor Influence on the Current Distributions During Transcranial Direct Current Stimulation

Changes in the Sensory Function after Transcranial Direct Stimulation on Dorsolateral Prefrontal Cortex Area

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