Treatment of bone tumours by radiofrequency thermal ablation

Santiago, Fernando Ruíz; García, María del Mar Castellano; Montes, José L.; García, Manuel Ruiz; Fernández, Juan Miguel Tristán

doi:10.1007/s12178-008-9042-3

Cited by 46 publications

(13 citation statements)

References 37 publications

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“…Radiofrequency thermal ablation is less invasive, and in our experience it had a mild effect in reducing the tumor's volume; therefore, we think it should be offered when complete surgical resection cannot be performed. 19 Propanolol was our last treatment attempt, intended to reduce vascularization of the tumor and therefore its growth. 20 In our experience there was mild improvement, with a reduction in tumor size 2 months after we initiated treatment.…”

Section: Figurementioning

confidence: 99%

Tumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report

et al. 2015

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Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decreased phosphate resorption. A 3-year-old boy presented with a limp and 6 months later with painless growth of the jaw. On examination gingival hypertrophy and genu varum were observed. Investigations revealed hypophosphatemia, normal 1,25 and 25 (OH) vitamin D, and high alkaline phosphatase. An MRI showed an osteolytic lesion of the maxilla. Radiographs revealed typical rachitic findings. Incisional biopsy of the tumor revealed a CGCG with mesenchymal matrix. The CGCG was initially treated with calcitonin, but the lesions continued to grow, making it necessary to perform tracheostomy and gastrostomy. One year after onset the hyperphosphaturia worsened, necessitating increasing oral phosphate supplements up to 100 mg/kg per day of elemental phosphorus. FGF23 levels were extremely high. Total removal of the tumor was impossible, and partial reduction was achieved after percutaneous computed tomography-guided radiofrequency, local instillation of triamcinolone, and oral propranolol. Compassionate use of cinacalcet was unsuccessful in preventing phosphaturia. The tumor slowly regressed after the third year of disease; phosphaturia improved, allowing the tapering of phosphate supplements, and FGF23 levels normalized. Tumor-induced osteomalacia/rickets is uncommon in children and is challenging for physicians to diagnose. It should be suspected in patients with intractable osteomalacia or rickets. A tumor should be ruled out if FGF23 levels are high.Tumor-induced osteomalacia/rickets (TIO) is a rare paraneoplastic disorder caused by overproduction of fibroblast growth factor 23 (FGF23) from the responsible tumors. 1,2 FGF23 is a hormone associated with decreased resorption of phosphate that causes hyperphosphaturia, leading to osteomalacia or rickets. [3][4][5] Tumors are typically benign, small, and with mesenchymal origin. 2,[6][7][8] We report the first pediatric case of TIO in association with a central giant cell granuloma (CGCG). 9 Our case is unique because the child presented with clinical signs of rickets as the first sign of CGCG with high FGF23 serum levels. PATIENT PRESENTATIONA previously healthy 3-year-old boy with no history of trauma or other joint problems presented with an increasing limp. Initial radiographs and basic laboratory studies, including calcium and phosphate, were normal. He initially received a diagnosis of

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Section: Figurementioning

confidence: 99%

Tumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report

et al. 2015

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“…Moreover, a limited consolidation effect can be reached, especially in vertebral and pelvic metastases (8). A limited number of clinical studies evaluated the combination of cementoplasty with thermal ablation procedures such as radiofrequency (9)(10)(11)(12)(13)(14)(15)(16)(17)(18), microwave (19,20) or cryoablation (17,(21)(22)(23)(24), as well as with embolization (24,25).…”

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confidence: 99%

CT fluoroscopy-guided percutaneous osteoplasty with or without radiofrequency ablation in the treatment of painful extraspinal and spinal bone metastases: technical outcome and complications in 29 patients

Burgard

Dinkel

Strobl

et al. 2018

Diagn Interv Radiol

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“… 6 For patients with unresectable GCTB, the use of chemotherapeutics, bisphosphonates, radiation, radiofrequency thermal ablation and arterial embolization are palliative options with limited effects on tumor control. 7 , 8 , 9 Recently, denosumab, a RANKL inhibitor, has been approved for GCTB, and it targets, especially the neoplastic stromal cells, which express high concentrations of RANKL. 9 , 10 …”

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confidence: 99%

Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib

et al. 2014

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Giant cell tumor of bone (GCTB) is a very rare tumor entity, which is little examined owing to the lack of established cell lines and mouse models and the restriction of available primary cell lines. The stromal cells of GCTB have been made responsible for the aggressive growth and metastasis, emphasizing the presence of a cancer stem cell population. To identify and target such tumor-initiating cells, stromal cells were isolated from eight freshly resected GCTB tissues. Tumorigenic properties were examined by colony and spheroid formation, differentiation, migration, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, immunohistochemistry, antibody protein array, Alu in situ hybridization, FACS analysis and xenotransplantation into fertilized chicken eggs and mice. A sub-population of the neoplastic stromal cells formed spheroids and colonies, differentiated to osteoblasts, migrated to wounded regions and expressed the metastasis marker CXC-chemokine receptor type 4, indicating self-renewal, invasion and differentiation potential. Compared with adherent-growing cells, markers for pluripotency, stemness and cancer progression, including the CSC surface marker c-Met, were enhanced in spheroidal cells. This c-Met-enriched sub-population formed xenograft tumors in fertilized chicken eggs and mice. Cabozantinib, an inhibitor of c-Met in phase II trials, eliminated CSC features with a higher therapeutic effect than standard chemotherapy. This study identifies a c-Met+ tumorigenic sub-population within stromal GCTB cells and suggests the c-Met inhibitor cabozantinib as a new therapeutic option for targeted elimination of unresectable or recurrent GCTB.

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Treatment of bone tumours by radiofrequency thermal ablation

Cited by 46 publications

References 37 publications

Tumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report

Tumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report

CT fluoroscopy-guided percutaneous osteoplasty with or without radiofrequency ablation in the treatment of painful extraspinal and spinal bone metastases: technical outcome and complications in 29 patients

Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib

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