Treatment of bone loss in osteopenic patients with Crohn's disease: a double-blind, randomised trial of oral risedronate 35 mg once weekly or placebo, concomitant with calcium and vitamin D supplementation

Bodegraven, Ad A. van; Bravenboer, Nathalie; Witte, B.I.; Dijkstra, Gerard; Woude, C. Janneke van der; Stokkers, Pieter; Rüssel, Maurice G.; Oldenburg, Bas; Pierik, Marieke; Roos, Jan C.; Hogezand, R. A. van; Dik, Vincent K.; Oostlander, A.E.; Netelenbos, J. C.; Langerijt, L. van de; Hommes, Daniël W.; Lips, Paul

doi:10.1136/gutjnl-2013-305523

Cited by 20 publications

(17 citation statements)

References 33 publications

(36 reference statements)

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“…Correction of vitamin D deficiency is recommended on the basis of bone health alone. 86 Increasing dietary fibre intake in maintenance of ulcerative colitis has some support, 87 but it is not clear what fibre should be used. The use of personalized whole-food avoidance strategies in maintenance of remission in Crohn's disease is a challenging technique and the increment of benefit demonstrated is not great.…”

Section: Prevention Of Relapsementioning

confidence: 99%

Dietary management of IBD—insights and advice

Halmos

Gibson

2015

Nat Rev Gastroenterol Hepatol

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The current general interest in the use of food choice or diet in maintaining good health and in preventing and treating disease also applies to patients with IBD, who often follow poor or nutritionally challenging dietary plans. Unfortunately, dietary advice plays only a minor part in published guidelines for management of IBD, which sends a message that diet is not of great importance. However, a considerable evidence base supports a focused and serious attention to nutrition and diet in patients with IBD. In this Review, a step-wise approach in the evaluation and management of these patients is proposed. First, dietary intake and eating habits as well as current nutritional state should be documented, and corrective measures instituted. Secondly, dietary strategies as primary or adjunctive therapy for the reduction of inflammation and/or prevention of relapse of IBD should be seriously contemplated. Thirdly, use of diet to improve symptoms or lessen the effects of complications should be considered. Finally, dietary advice regarding disease prevention should be discussed when relevant. An increasing need exists for applying improved methodologies into establishing the value of current and new ways of using food choice as a therapeutic and preventive tool in IBD.

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Section: Prevention Of Relapsementioning

confidence: 99%

Dietary management of IBD—insights and advice

Halmos

Gibson

2015

Nat Rev Gastroenterol Hepatol

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“…98 This is in agreement with a recently published study by van Bodegraven et al, where treatment with bisphosphonates concomitantly with vitamin D (800 IU) and calcium (1 000 g) supplementation in osteopenic CD patients had a more beneficial effect on BMD than supplementation with vitamin D and calcium alone. 100 …”

Section: Osteoporosismentioning

confidence: 99%

Vitamin D Therapy in Inflammatory Bowel Diseases: Who, in What Form, and How Much?

Hlavatý

Krajčovičová

Payer

2014

Journal of Crohn's and Colitis

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Background: The north-south geographical gradient of inflammatory bowel disease (IBD) prevalence, its epidemiology, the genetic association of vitamin D receptor polymorphisms, and results in animal models suggest that vitamin D plays an important role in the pathogenesis of IBD. Aims: The purpose of this review was to critically appraise the effectiveness and safety of vitamin D therapy in patients with IBD.

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“…A 24-months treatment course with risedronate 35 mg once weekly, concomitant with calcium and Vitamin D supplementation, in osteopenic IBD patients improved bone density [26]. Similar studies are urgently needed in Celiac Disease.…”

Section: Follow Up and Bonesmentioning

confidence: 83%

Preventing complications in celiac disease: Our experience with managing adult celiac disease

Mulder

Wierdsma

Berkenpas

et al. 2015

Best Practice & Research Clinical Gastroenterology

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Treatment of bone loss in osteopenic patients with Crohn's disease: a double-blind, randomised trial of oral risedronate 35 mg once weekly or placebo, concomitant with calcium and vitamin D supplementation

Abstract: A 24-month treatment course with risedronate 35 mg once weekly, concomitant with calcium and vitamin D supplementation, in osteopenic Crohn's disease patients improved bone density at lumbar spine. NTR 163 Dutch Trial Register.

Cited by 20 publications

References 33 publications

Dietary management of IBD—insights and advice

Dietary management of IBD—insights and advice

Vitamin D Therapy in Inflammatory Bowel Diseases: Who, in What Form, and How Much?

Preventing complications in celiac disease: Our experience with managing adult celiac disease

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