Treatment of Blepharitis: Recent Clinical Trials

Loteprednol Etabonate 0.5%/Tobramycin 0.3% Compared with Dexamethasone 0.1%/Tobramycin 0.3% for the Treatment of Blepharitis

“…While the study design allowed for a robust comparison of the two treatments, it cannot be known whether the improvement in blepharitis signs was attributed to the steroid, the antibacterial, or to the combination, although we assume that improvement was likely due to the combination of both, given that concurrent bacterial infection and inflammation are likely at play in many cases of blepharitis. 1,4 Furthermore, because patients in the source studies were initially selected for study based upon a broader diagnosis of BKC, not blepharitis, specifically, non-drug measures encouraged for the management of blepharitis, such as lid hygiene and warm compresses, 1 were not included. Finally, given the chronic nature of blepharitis, the 2-week follow-up period may not have been sufficient to evaluate the full efficacy of LE/T and DM/T for this indication.…”

“…3 The pathology of the condition is not yet completely understood, but low-grade bacterial infection (primarily Staphylococcus), Demodex mites, environmental factors, and certain systemic disease, have all been implicated as potential contributors. 1,4 Blepharitis can be difficult to treat, usually with little chance of a complete cure. 1,2 The chronic discomfort caused by blepharitis and its impact on appearance may be a source of physical and psychological distress for patients, including anxiety and depression.…”

“…5,6 While there are no products approved by the US Food and Drug Administration (FDA) specifically for the treatment of blepharitis, current therapeutic approaches aim to control and minimize symptoms and signs of inflammation. 4 The most recent guidelines of the American Academy of Ophthalmology (AAO) identify various treatments that may be helpful alone or in combination, including warm compresses, eyelid cleansing/ massage, topical and/or systemic antibiotics, and topical anti-inflammatory agents, such as corticosteroids and cyclosporine. 1 Topical antibiotic-corticosteroid combination products are useful for decreasing the bacterial load as well as managing inflammation.…”

Medical management of blepharitis

“…Blepharitis is a chronic inflammatory condition of the eyelids and is typically classified into anterior and posterior blepharitis [1,2]. It is among the most common ocular conditions, affecting up to 47% of patients seen in the clinical setting [1,3].…”

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

“…Peri-ocular conditions occur around the eye and can cause irritation to different parts of the eye, e.g. blepharitis, trachoma, conjunctivitis, and dry eye [52]. Intraocular conditions represent the infection of the inner parts of the eye and can affect the retina, the iris, the aqueous and the vitreous humour, with the most common being glaucoma.…”