Treatment of Bilateral Endogenous <b><i>Aspergillus</i></b> Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome

Abstract

Endogenous endophthalmitis caused by &lt;i&gt;Aspergillus&lt;/i&gt; species tends to be very aggressive, often leading to devastating visual outcomes. Historically, intravitreal amphotericin injections have played a central role in management, but with variable visual outcomes and a risk of toxicity. Limited reports suggest that use of intravitreal voriconazole is a safe and efficacious alternative, though these cases were treated with only few intravitreal injections. Here, we report a case of bilateral endogenous &lt;i&gt;Aspergillus&lt;/i&gt; endophthalmitis treated with 8 intravitreal voriconazole injections in the right eye and 11 in the left eye with good best-corrected final visual outcome (20/50 right eye and 20/40 left eye).