Treatment of Behçet Disease With Chlorambucil

Management of Behcet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behcet disease

“…Open studies with chlorambucil have shown some efficacy for eye84 85 86 87 88 and neurological involvement,89 however serious toxicities such as leukopoenia and thrombocytopoenia were observed. Another major drawback is the increased risk of malignancies.…”

Behçet’s disease and the alimentary tract

“…The role of antimucosal antibodies is uncertain, since these may be secondary to ulceration, and are detectable in aphthous ulceration with no other stigmata of Behret's disease (Lehner, 1964(Lehner, , 1967O'Duffy, Carney and Deodhar, 1971). In contrast, Dolby (1972) (Mamo and Azzam, 1970;Rosselet, Saundan and Zenklusen, 1968) while other workers have been less impressed (Wong, 1969). Haim and Sherf (1966) reported a transient favourable response to transfusion of fresh blood or plasma, and O' Duffy et al (1971) were also impressed by this effect: we did not note any such response to blood transfusion in our patients,'but blood was given only as indicated and no trial of this therapy was undertaken.…”

Corticosteroids and Anti-Complement Therapy in Retinal Diseases

“…Alternatively, high-dose therapy may be offered, consisting of 2 mg per day for 1 week followed by 2 mg per day each week until quiescence is achieved, the WBC count decreases to 2,400 cells per microliter or the platelet count drops below 100,000 cells per microliter (Larson et al 2011;Tessler and Jennings 1990;Mamo 1976). Upon initiation of treatment, complete blood count should be checked weekly and eventually monthly, once values have stabilized.…”