Treatment of behavioral problems in intellectually disabled adult patients with epilepsy

Abstract

SUMMARYBehavioral disorders are common in people with epilepsy and intellectual disability. Although in some genetic disorders behavioral problems are part of the established phenotype, they may also be a manifestation of underlying physical or mental illness, or may be unrecognized seizure activity. In light of this, assessment of behavioral disorders should take into account person factors such as the physical health and mental state of the person and environmental factors such as the quality of their interactions with carers and their living conditions. Video-electroencephalography ( EEG) is recommended where possible. We review potential pharmacologic and behavioral management strategies for behavioral disorders in people with intellectual disability.

Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells

“…Various epidemiological studies indicate the associations between cataract prevalence and epilepsy is equivalent to association of cataract with aging, diabetes, arterial hypertension and smoking (Hanhart et al, 2010; Isaac et al, 1991; Kato et al, 1990; Kinoshita et al, 2004; Kuwabara et al, 2009; Mathers et al, 1987). The onset of epilepsy is due to over-synchronous firing of brain neurons (Kerr et al, 2013) and these firing patterns are modulated by a major excitatory neurotransmitter, glutamate, through the family of glutamate receptors (Kim et al, 2004). …”

Determinants of health and wellbeing in refractory epilepsy and surgery: The Patient Reported, ImpleMentation sciEnce (PRIME) model

“…The literature emphasizes that there is always an interplay between physical and psychosocial domains in epilepsy [51,52], while the World Health Organization (WHO) (2014) has recommended a thorough investigation of the way that social environments and social connections shape not only physical but also mental health outcomes [53]. The position of the WHO was preceded by the work of Jacoby and Baker [21].…”

Trend of Disabled Person Care for Establishment of Visiting Health Management Model for the Disabled

“…의과 연구의 경우 단면조사연구가 1편 30) , 비무작위대 조 임상연구 1편 31) , 단일군 전후비교 연구가 2편 32,33) , 후 향적 차트 리뷰 2편 34,35) 이 보고되었다. 증례보고가 1편 36) , 기타 단순 보고서나 문헌고찰이 4편 [37][38][39][40] 이 보고되었다 (Table II).…”

“…(2) 연구자 선정된 연구들에서 13편의 연구가 치과 치료 관련 연 구 [17][18][19][20][21][22][23][24][25][26][27][28][29] 였으며, 나머지 11편은 모두 의과 치료 관련 연구 [30][31][32][33][34][35][36][37][38][39][40] 이었다( Table II).…”

“…( 17,20,26,27,29) , 의과 치료 3편 31,32,39) ), 발달장애 환자에 대한 치과 치료 연구 1편 18) , 신체/정신/감각장애 환자에 대한 치과 치료 연구 1편 19) , 인지장애에 대한 치과 치료 연구 1편 21) , 다 운증후군 등에 대한 치과 치료 연구 1편 22) , 정신지체장 애에 대한 의과 치료 연구 2편 33,38) , 간질(epilepsy) 환자 this study suggest that underlying medical or mental conditions may influence the dental condition and treatment modality provided. www.e-jkmr.org 69 에 대한 의과 치료 연구 2편 34,37) , 뇌성마비(cerebral palsy)에 대한 의과 치료 연구 1편 36) , Phelan-McDermid syn-drome에 대한 연구 1편 40) , 그리고 장애의 종류를 명시 하지 않은 연구 6편(치과 치료 [23][24][25]28) , 의과 치료 30,35) ) 등 다양한 장애 유형에 대한 연구가 보고되었다 (Table II)…”