Treatment of Bacterial Vaginosis in Early Pregnancy and its Effect on Spontaneous Preterm Delivery and Preterm Premature Rupture of Membranes

Larsson, Per Göran; Poutakidis, Georgios; Adolfsson, Annsofie; Charonis, Georgios; Bauer, Pasi; Ekström, Linnéa

doi:10.4172/2327-5073.1000259

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…The prevalence of 16.6% recorded in this study lies within the documented reported prevalence of 6%-32% from studies conducted in different regions of the world [17]. This prevalence is also consistent with figures reported from south-east and north-east Nigeria by Adinma et al [11] and Ibrahim et al [12] but higher than finding of Larrson et al [18] and lower than findings of Afolabi et al [19] and Isik et al [20]. Higher prevalence rates of bacterial vaginosis than in the present study were also reported from other sub-Saharan countries such as Kenya, Botswana, and Zimbabwe [21].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Aduloju¹,

Akintayo²,

Aduloju³

2019

Pan Afr Med J

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Introduction Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of child bearing age. Bacterial vaginosis has emerged as a global health issue due to the adverse outcome in pregnancy and in the puerperium. The study determined the prevalence of BV and outcome of delivery among pregnant women. Methods Socio-demographic data and vaginal swab samples were obtained from 362 consecutive pregnant women with abnormal vaginal discharge attending antenatal clinic in Ekiti State University Teaching Hospital, Ado-Ekiti. Data were analysed using SPSS statistical software 21 and association between variables was compared using Chi square. Results The prevalence of BV among pregnant women with abnormal vaginal discharge in this study was 16.6%. Age group 25-34yrs, multiparity and higher education were significantly associated with BV, p < 0.05. Symptoms such as vulvar itching, dyspareunia, lower abdominal pains and characteristic of vaginal discharge such as colour and consistency were significantly associated with BV, p < 0.05. Women with bacterial vaginosis significantly had prelabour rupture of fetal membrane and their babies were born prematurely with low birth weight and Apgar score of less than 5 at one minute, p < 0.05. However, there was no difference statistically in rate of admission into special care baby unit among the women, p > 0.05. Conclusion The findings of this study suggest that there should be screening for BV in pregnant women presenting with abnormal vaginal discharge so that they could be treated accordingly. This will mitigate the complications arising from bacterial vaginosis.

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Section: Discussionsupporting

confidence: 92%

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Aduloju¹,

Akintayo²,

Aduloju³

2019

Pan Afr Med J

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“…For intravaginal antibiotic preparations, consistent declines in the prevalence of use were apparent from 2015; but such trends have not been reported elsewhere; and as for systemic antibiotics, prevalence rates were lower than reported in Denmark overall (8.9%) and throughout the 13 years. 9 , 23 While intravaginal clindamycin and metronidazole are the first and second line treatments for bacterial vaginosis, which occurs in about 10% of the Swedish pregnant population, 21 , 38 the absence of routine screening may lead to untreated subclinical cases and the disparity with our prevalence rates. Intestinal antibiotic preparations were seldom used, as those currently available on the Swedish market are used to treat Clostridioides difficile infections, whose incidence is extremely low.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007–2019

Nakitanda,

Odsbu,

Pasternak

et al. 2023

Acta Obstet Gynecol Scand

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IntroductionAntibiotics are often prescribed during pregnancy. Assessing the current state of prenatal antibiotic use is therefore imperative for optimizing prescribing and identifying emerging research priorities. The study aimed to describe recent trends and patterns in antibiotic use during pregnancy among women who gave birth in Sweden, including user characteristics.Material and methodsPopulation‐based descriptive study using linked nationwide registers. All pregnancies delivered in Sweden from 2007 to 2019 were included. Prevalence of use was defined as the percentage of pregnancies during which at least one prescription forantibiotics was filled. Temporal trends in the prevalence of antibiotic use by calendar year, trimester and weeks of gestation were assessed from time series graphs.ResultsPrescriptions for systemic antibiotics were filled in 20.7% of 1 434 431 pregnancies overall, decreasing from 24.7% in 2007 to 18.0% in 2019. Phenoxymethylpenicillin (8.5%), pivmecillinam (6.5%), nitrofurantoin (4.7%), amoxicillin (1.6%) and cefadroxil (1.5%) use were the most prevalent. Their use decreased over the 13‐year period, except for pivmecillinam, which increased from 4.0% to 7.4%. Prevalence of use was highest in the second trimester (9.5%), with weekly trends peaking at 13 and 34 weeks of gestation. Compared with non‐users, antibiotic users more often belonged to the youngest and oldest age strata, carried multipleton pregnancies, had delivered before, had attained a lower education level and smoked in early pregnancy. A higher body mass index, asthma, chronic renal disease and diabetes mellitus were more prevalent among antibiotic users than among non‐users.ConclusionsAlthough outpatient antibiotic use during pregnancy in Sweden has been declining, one in five pregnancies was exposed to systemic antibiotics.

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“…Sometimes because of the similarity of the symptoms of bacterial vaginosis are confused with those of candida and treated accordingly. To differentiate between the two it is necessary to examine the discharge culture with a microscopic examination [32].…”

Section: Discussionmentioning

confidence: 99%

How Vaginal Infections Impact Women’s Everyday Life <br/>—Women’s Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis

Adolfsson¹,

Hagander²,

Mahjoubipour³

et al. 2017

ASM

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Reoccurring symptoms and persistent problems that continue post treatment can be characteristic of the vaginal infections Bacterial Vaginosis (BV) and recurrent vulvovaginal candidiasis (RVVC). The purpose of this study was to describe women's life experiences in managing the symptoms of bacterial vaginosis and Candida. Sixteen women were recruited and participated in an interview study when they contacted a Swedish gynecology clinic with vaginal complaints that ranged from and included abnormal discharge, irritation itching along with serious malodor. An interpretive phenomenological approach was used with an individual interview to get a more intimate understanding of the women experiencing these problems. The finding of this study shows that managing the recurrent symptoms of the infections remains to be a challenge for women as it has a clearly negative impact on the quality of their lives. Four themes developed: frustration and mood disorders, intimacy changes in the relationship, exposure, hope and relief. The women had high hopes of eliminating the symptoms within the six-month study period. The treatment program, with its well-developed guidelines and continuity of care within the context of the study greatly improved the quality of life of these women. Women had feelings of frustration and anxiety when nothing could cure their problem while they had also a great hope to get rid of the symptoms with a long striking treatment. Well-developed guidelines and continuity of care can help these women to have an improved quality of life.

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Treatment of Bacterial Vaginosis in Early Pregnancy and its Effect on Spontaneous Preterm Delivery and Preterm Premature Rupture of Membranes

Cited by 8 publications

References 18 publications

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007–2019

How Vaginal Infections Impact Women’s Everyday Life <br/>—Women’s Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis

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Treatment of Bacterial Vaginosis in Early Pregnancy and its Effect on Spontaneous Preterm Delivery and Preterm Premature Rupture of Membranes

Cited by 8 publications

References 18 publications

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Prevalence of bacterial vaginosis in pregnancy in a tertiary health institution, south western Nigeria

Antibiotic use during pregnancy in Sweden: A nationwide utilization study covering 2007–2019

How Vaginal Infections Impact Women’s Everyday Life &lt;br/&gt;—Women’s Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis

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How Vaginal Infections Impact Women’s Everyday Life <br/>—Women’s Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis