Treatment of autonomous thyroid nodules with percutaneous ethanol injection: preliminary results. Work in progress.

Livraghi, Tito; Paracchi, A.; Ferrari, C; Bergonzi, M; Garavaglia, Guido; Raineri, P; Vettori, C

doi:10.1148/radiology.175.3.2188302

Cited by 175 publications

(97 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They all have some advantages on surgery: no hiatrogenic hypothyroidism, no scar formation, lesser costs. Adverse events are comparable: the most common major adverse effect, recurrent laryngeal nerve palsy, is 11.8% (9.8% transient, 2% permanent) in surgery (18) and 0-8% (only transient) in RFA and LA (6)(7)(8)17,(19)(20)(21)(22)(23). PEI has revealed to be useful for cystic nodules: it can be used with fine needles (21G), and is quite inexpensive and shows good results (53-80% reduction in volume) (24).…”

Section: Discussionmentioning

confidence: 99%

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Morelli¹,

Sacrini²,

Pompili³

et al. 2016

Gland Surg.

View full text Add to dashboard Cite

Background: Thyroid nodules are a fairly common finding in general population and, even if most of them are benign, a treatment can be however necessary. In the last years, non surgical minimally invasive techniques have been developed to treat this pathology, starting from percutaneous ethanol injection (PEI), to laser ablation (LA), radiofrequency ablation (RFA) and, most recently, microwave ablation (MWA). Methods:We reviewed all medical literature searching in pubmed.gov the terms "microwave" & "thyroid".We found three original studies concerning MWA treatment, for a total of 263 patients (mean age 51.0 years; range, 15-80 years; male to female ratio 2.55) and 522 nodules.Results: A total of 522 nodules (338 solid, 22 cystic, 162 mixed) in 263 patients were treated. Studies have shown a mean reduction in volume of thyroid nodules ranging from 45.9% to 65%. No study reported a significant and definitive change in laboratory parameters, except for one case (Heck et al.). No studies have reported major complications after procedure.Conclusions: MWA is a new, promising technique among the minimally invasive treatments of thyroid nodules. Actually, the larger diameter of MW antenna seems to be the major limiting factor in the use of this technique. More studies are necessary to evaluate feasibility, safety and efficacy of the procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Morelli¹,

Sacrini²,

Pompili³

et al. 2016

Gland Surg.

View full text Add to dashboard Cite

show abstract

“…Em 1990, Livraghi e cols. (32) propuseram o seu uso para o tratamento de nódulos tiroidianos autônomos, obtendo regressão anatômica das lesões e cura da disfunção glandular. Na última década, vários grupos, especialmente europeus, têm confirmado os bons resultados desta terapia, tanto em nódulos tóxicos (6,33,34) como atóxicos e císticos (7,22,36).…”

Section: Alcoolização De Nódulo Tiroidianounclassified

Alcoolização de nódulo tiroidiano em região endêmica de bócio colóide

Lima¹,

Fagundes

Raffaelli³

et al. 2007

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

RESUMOA doença nodular tiroidiana é problema clínico comum, principalmente em regiões com carência de iodo. Esse estudo avaliou a eficácia da injeção percutânea de etanol (IPE) no tratamento de nódulos tiroidianos únicos, múltiplos, sólidos, císticos, de diferentes tamanhos com ou sem disfunção glandular, em região endêmica de bócio. Quarenta e dois pacientes com diagnóstico de bócio colóide ou hiperplasia nodular colóide, na punção biópsia aspirativa por agulha fina (PBAAF), foram selecionados para análise após terem sido submetidos a pelo menos duas IPEs. Os nódulos tiroidianos eram múltiplos (sólidos e ou císticos) em 52,4% dos pacientes, únicos e sólidos ou mistos em 35,7% e únicos e císticos em 11,9%. A redução média dos nódulos após injeção de etanol foi de 58,2% para os únicos e 60,8% nos císticos. ABSTRACT Alcoholization in the Treatment of Thyroid Nodule in Colloid Goiter Endemic Region.Thyroid nodular disease is a common clinical disorder mainly in iodine lacking regions. This study has evaluated the effectiveness of percutaneous ethanol injection (PEI) in the treatment of single, multiple, solid, and cystic thyroid nodules of different sizes with or without glandular dysfunction, in goiter endemic region. Forty-two patients with diagnosis of colloid goiter or colloid nodular hyperplasia in fine-needle aspiration (FNA) were selected for analysis, after having been submitted to at least two PEI. Thyroid nodules were multiple (solid and or cystic) in 52.4% of the patients, single and solid or mixed in 35.7%, and single and cystic in 11.9%. The mean reduction of nodules after ethanol injection was of 58.2% in the single and of 60.8% in the cystic ones. The reduction of the whole thyroid lobe was evaluated in the multiple nodules and it reached 52.4%. The sideeffects were registered only as a consequence of the application discomfort. This study points out that the percutaneous ethanol injection reaching volume mean reductions, varying from 49% to 60%, is a safe, effective, and simple method for the treatment of benign thyroid nodules.

show abstract

“…Monitoramos as injeções por meio da observação ao US, para evitar o escape extranodular e permitir a otimização da difusão do etanol (4,24). Nos nódulos sólidos, a quantidade de etanol injetada em cada sessão dependeu do volume do nódulo, correspondendo a cerca de 20-30% do volume nodular calculado previamente.…”

Section: Métodosunclassified

“…Os efeitos colaterais da injeção do etanol são descritos, nas várias séries, de fracos a moderados e são sempre transitórios, sendo a dor local no momento da aplicação o principal sintoma (4,(19)(20)(21).…”

unclassified

Injeção percutânea de etanol no tratamento de nódulos tiroidianos sólidos, císticos e autônomos

Bianchini

Ikejiri

Mamone

et al. 2003

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

RESUMOA injeção percutânea de etanol (IPE) guiada por ultra-som tem sido utilizada para o tratamento de nódulos tiroidianos autônomos, sólidos e cís-ticos. Apresentamos nossa experiência em 50 pacientes tratados, sendo 26 portadores de nódulos sólidos, 17 de nódulos císticos e 7 de nódulos autônomos (NA). Avaliamos os pacientes 1 semana, 1 mês, 3 meses, 6 meses e 1 ano após a IPE. Após 1 ano, os nódulos sólidos reduziram a 74% do volume inicial, os císticos diminuíram 92% sem apresentar recidivas. Um ano após o tratamento dos nódulos autônomos, 5 pacientes estavam em eutiroidismo clínico e laboratorial e 2 em eutiroidismo mas com TSH subnormal. Não houve recorrência da tirotoxicose e a redução nodular foi de 66%. O procedimento foi bem tolerado por todos. Os resultados confirmam que a IPE é uma boa alternativa terapêutica para redução dos nódulos tiroidianos císticos e sólidos e no tratamento dos nódulos autônomos. Percutaneous ethanol injection (PEI) guided by ultrasound has been used for the treatment of cystic, solid and autonomous thyroid nodules. We present our experience in the treatment of 50 patients with thyroid nodules: 26 solid, 17 cystic and 7 autonomous (AN). Patients were evaluated 1 week, 1, 3, and 6 months and 1 year after PEI. After one year, solid nodules showed a mean 74% volume reduction, and cysts a volume reduction of 92%, with no recurrences. After one year, 5 patients with AN reached clinical and laboratory euthyroidism; the other 2 also became euthyroid, but with subnormal TSH. Recurrence of thyrotoxicosis was not observed and mean nodular reduction was 66%. The procedure was well tolerated by all patients. The results confirm that PEI is a good therapeutic alternative for reduction of solid and cystic thyroid nodules and for the treatment of autonomous nodules. (4) propuseram seu uso para o tratamento de nódu-los tiroidianos autônomos hiperfuncionantes e obtiveram regressão anatômica das lesões e cura da disfunção glandular. Na última década,

show abstract

Treatment of autonomous thyroid nodules with percutaneous ethanol injection: preliminary results. Work in progress.

Cited by 175 publications

References 0 publications

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?

Alcoolização de nódulo tiroidiano em região endêmica de bócio colóide

Injeção percutânea de etanol no tratamento de nódulos tiroidianos sólidos, císticos e autônomos

Contact Info

Product

Resources

About