Treatment of asthma exacerbations with the human-powered nebuliser: a randomised parallel-group clinical trial

Hallberg, Christopher J; Lysaught, M. Therese; Najarro, René Antonio; Gil, Fausto Cea; Villatoro, Clara; Uriarte, Ana Celia Diaz de; Olson, L. Karl

doi:10.1038/npjpcrm.2014.16

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The purpose of this study was to compare the performance of the HPN to an electric nebulizer compressor on key performance measures: volume delivery, pressure and flow characteristics, and delivered particle size distribution. The present study complements two published clinical trials that have demonstrated equivalence between the HPN and an electric nebulizer for the production of sputum samples for TB diagnosis [ 22 ] and for the treatment of patients with mild to moderate asthma exacerbations [ 23 ].…”

Section: Introductionmentioning

confidence: 55%

Characterization of a human powered nebulizer compressor for resource poor settings

et al. 2014

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BackgroundRespiratory disease accounts for three of the ten leading causes of death worldwide. Many of these diseases can be treated and diagnosed using a nebulizer. Nebulizers can also be used to safely and efficiently deliver vaccines. Unfortunately, commercially available nebulizers are not designed for use in regions of the world where lung disease is most prevalent: they are electricity-dependent, cost-prohibitive, and not built to be reliable in harsh operating conditions or under frequent use.To overcome these limitations, the Human Powered Nebulizer compressor (HPN) was developed. The HPN does not require electricity; instead airflow is generated manually through a hand-crank or bicycle-style pedal system. A health care worker or other trained individual operates the device while the patient receives treatment.This study demonstrates functional specifications of the HPN in comparison with a standard commercially available electric jet nebulizer compressor, the DeVilbiss Pulmo-Aide 5650D (Pulmo-Aide).MethodsPressure and flow characteristics were measured with a rotameter and pressure transducer, respectively. Volume nebulized by each compressor was determined by mass, and particle size distribution was determined via laser diffraction. The Hudson RCI Micro Mist nebulizer mouthpiece was used with both compressors.ResultsThe pressure and flow generated by the HPN and Pulmo-Aide were: 15.17 psi and 10.5 L/min; and 14.65 psi and 11.2 L/min, respectively. The volume of liquid delivered by each was equivalent, 1.097 ± 0.107 mL (mean ± s.e.m., n = 13) for the HPN and 1.092 ± 0.116 mL for the Pulmo-Aide. The average particle size was also equivalent, 5.38 ± 0.040 micrometers (mean ± s.e.m., n = 7) and 5.40 ± 0.025 micrometers, respectively.ConclusionsBased on these characteristics, the HPN’s performance is equivalent to a popular commercially available electric nebulizer compressor. The findings presented in this paper, combined with the results of two published clinical studies, suggest that the HPN could serve as an important diagnostic and therapeutic tool in the fight against global respiratory health challenges including: tuberculosis, chronic obstructive pulmonary disease, asthma, and lower respiratory infections.

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Section: Introductionmentioning

confidence: 55%

Characterization of a human powered nebulizer compressor for resource poor settings

et al. 2014

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“…I was intrigued by the recent article by Hallberg et al . 1 on a human-powered nebuliser as such equipment has been used throughout the world for many years. In 1981 Shann 2 described giving asthma treatment by a foot pump-driven nebuliser in Papua New Guinea.…”

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confidence: 99%

Medical foot pump compressors have been available for many years as an option for human powered nebulisation

Masters¹

2014

npj Prim Care Resp Med

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Bioengineering and Clinical Translation of Human Lung and its Components

et al. 2023

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Clinical lung transplantation has rapidly established itself as the gold standard of treatment for end‐stage lung diseases in a restricted group of patients since the first successful lung transplant occurred. Although significant progress has been made in lung transplantation, there are still numerous obstacles on the path to clinical success. The development of bioartificial lung grafts using patient‐derived cells may serve as an alternative treatment modality; however, challenges include developing appropriate scaffold materials, advanced culture strategies for lung‐specific multiple cell populations, and fully matured constructs to ensure increased transplant lifetime following implantation. This review highlights the development of tissue‐engineered tracheal and lung equivalents over the past two decades, key problems in lung transplantation in a clinical environment, the advancements made in scaffolds, bioprinting technologies, bioreactors, organoids, and organ‐on‐a‐chip technologies. The review aims to fill the lacuna in existing literature toward a holistic bioartificial lung tissue, including trachea, capillaries, airways, bifurcating bronchioles, lung disease models, and their clinical translation. Herein, the efforts are on bridging the application of lung tissue engineering methods in a clinical environment as it is thought that tissue engineering holds enormous promise for overcoming the challenges associated with the clinical translation of bioengineered human lung and its components.

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Treatment of asthma exacerbations with the human-powered nebuliser: a randomised parallel-group clinical trial

Cited by 3 publications

References 15 publications

Characterization of a human powered nebulizer compressor for resource poor settings

Characterization of a human powered nebulizer compressor for resource poor settings

Medical foot pump compressors have been available for many years as an option for human powered nebulisation

Bioengineering and Clinical Translation of Human Lung and its Components

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