Treatment of aseptic diaphyseal nonunion of the lower extremities with exchange intramedullary nailing and blocking screws without open bone graft

Abstract

The therapeutic method of exchanging the nail combined with blocking screws is effective for aseptic nonunion of the lower extremity after intramedullary nailing.

Reaming in treatment of non-unions in long bones: cytokine expression course as a tool for evaluation of non-union therapy

“…Our method is a reliable method for detecting changes and processes of bone metabolism based on cytokine expression. This was demonstrated in patients who underwent intramedullary reaming, a well-established standard procedure in nonunion therapy: the high concentrations of mesenchymal stem cells, growth, and differentiation factors within the reaming debris promote solid bone healing and the expression of further cytokines at both, the fracture site, and systemically [12,13,15,25,28]. For example, TGF-ß1 levels in both G1 and G2 peaked after 6 weeks.…”

Results of a Systematic Approach to Exchange Nailing for the Treatment of Aseptic Tibial Nonunions

“…[1][2][3][4][5][6][7][8][9] These prior reports have been summarized elsewhere, 10,11 but healing rates seem to be related to the presence or absence of a partial segmental defect, 7 time from fracture to exchange nailing, fracture type, and fixation of the exchange nail (ie, static, dynamic, or unlocked). [1][2][3][4][5][6][7][8][9] These prior reports have been summarized elsewhere, 10,11 but healing rates seem to be related to the presence or absence of a partial segmental defect, 7 time from fracture to exchange nailing, fracture type, and fixation of the exchange nail (ie, static, dynamic, or unlocked).…”

Management of femoral diaphyseal nonunion after nailing with augmentative locked plating and bone graft

“…Nonunions usually occur secondary to unfavorable fracture patterns, poor reduction, and excessive soft tissue stripping or suboptimal position of internal fixation devices. Once nonunion has been detected, a successful treatment strategy should be based on the following three main goals: (i) achieving mechanical stability of the bone fragments; (ii) augmenting the potential for bone healing; and (iii) correcting any alignment deformity 7 .…”