Treatment of Argyria Using the Quality-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser: Efficacy and Persistence of Results at 1-Year Follow-Up

Acitretin, a synthetic retinoid has gradually replaced etretinate in today's dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of difficult-to-treat hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinflammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based efficacy, side-effect profile, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.

Section: Infectionsmentioning

confidence: 99%

Acitretin in dermatology

Sarkar¹,

Chugh²,

Garg³

2013

“…[5,6, It is worth mentioning herein, two reports of familial argyria in members of the same family due to prolonged use of silver containing formulations as a form of alternative medicine. [53,54] Apart from this, localized cases of argyria have also been reported following acupuncture. [55][56][57] Personal and socio-cultural Cases of argyria have been associated with certain personal and socio-cultural practices.…”

Section: Discussion Discussionmentioning

confidence: 99%

Follicular Dowling Degos disease: A rare variant of an evolving dermatosis

Singh

Khandpur

Verma

et al. 2013

Dowling Degos disease is a rare, reticulate pigmentary disorder with variable phenotypic expression that manifests as hyperpigmented macules and reticulate pigmentary anomaly of the flexures. Many variants of this condition and its overlap with other reticulate pigmentary disorders have been reported in the literature. We present here two cases of DDD with follicular localization, both clinically and histologically. It was associated with ichthyosis vulgaris in one case. Follicular DDD is an uncommon variant of this evolving dermatosis. Our report supports the possible role for disordered follicular keratinisation in its pathogenesis.

“…Recently, Q-switched 1064-nm neodymium-doped yttrium aluminium garnet laser has been reported to be useful for resolving the skin discoloration in argyria. [42,47,50,54] Indian perspective All the four cases of argyria, described in this article are due to intake of silver coated betel nut/cardamoms [ Table 1]. An extensive literature search conducted with the purpose to identify the reports of argyria pertaining to related forms of exposure yielded five citations.…”

Section: Discussion Discussionmentioning

confidence: 99%

Use of fine needle aspirate from peripheral nerves of pure-neural leprosy for cytology and PCR to confirm the diagnosis: A pilot study

Reja¹,

De²,

Biswas³

et al. 2013

Our study demonstrates that in the field of laboratory diagnosis of PNL cases, FNAC in combination with ZN staining for acid-fast bacilli (AFB) and Multiplex-PCR can provide a rapid and definitive diagnosis for the majority of PNL cases. FNAC is a less-invasive, outdoor-based and simpler technique than invasive nerve biopsy procedure. Thus, this study may enlighten the future path for easy and reliable diagnosis of PNL.