Treatment of Anxiety States With Meprobamate

Effects of meprobamate and prochlorperasine on positive and negative conditioning.

“…The experimental designs of most of these studies (like the present one) do not provide a crucial test between these alternative interpretations. But since there is abundant clinical evidence that tra.nquilizing drugs do decrease hyperexcitability and anxiety (Berger, Hendley, & Tynes, 1956;Osinski, 1957;Wilder, 1958) and some experimental data showing they also decrease the activation level as measured by the psychogalvanometer (Carran, 1960;Kristofferson & Cormack, 1960), our predictions are based on the assumption that tranquil izing drugs possess drive-altering properties.…”

Chlorpromazine, Reserpine and Meprobamate: Psychological Effects.

“…Lemere feels it is the drug of choice for relief of tension, anxiety, and insomnia. Osinski (86), in a clinical report of 113 outpatients who showed anxiety symptoms, describes "... definite effectiveness in psychoneurotic anxiety states." Thimann and Gauthier (90) noted diminished anxiety and agitation in over half of a group of 65 hospitalized alcoholic patients, and Perlstein ( 87) is led to speculate that meprobamate may help control epileptic seizures partly by diminishing anxieties and tensions which trigger them.…”