Treatment of an Acute Case of Plasmodium Malariae Malaria with Mefloquine

Abstract

Mefloquine, a new antimalarial which has been effective in curing malaria due to Plasmodium falciparum and P. vivax, was used for the first time in a patient infected with P. malariae. Treatment was successful, and the relatively long parasite clearance time and fever clearance time were probably characteristic of P. malariae rather than true drug resistance.

Cases of ovale malaria and malariae malaria successfully treated with mefloquine.

“…as mefloquine against ovale and malariae malaria are limited (Danis et al, 1982;Dixon et al, 1983;Coulaud et al, 1983) . Thus, 3 (Coulaud et al, 1983) and 4 (Danis et al.…”

“…In one report, one case of malariae malaria was treated with 1,500mg of mefloquine base with the fever clearance of 4 days and the parasite clearance of 7 days (Dixon et al, 1983) .…”