Treatment of Allergy to Cow's Milk

Kuzemko, J A; Simpson, Kellie

doi:10.1016/s0140-6736(75)91249-0

The Lancet

1975

DOI: 10.1016/s0140-6736(75)91249-0

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Treatment of Allergy to Cow's Milk

J A Kuzemko

Kellie Simpson

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1985

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Cited by 14 publications

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“…Diagnostic criteria were discussed by Walker-Smith (1975). Reports by Freier and Berger (1973) and Kuzemko and Simpson (1975) suggested that treatment with oral sodium cromoglycate might relieve symptoms. Two children are reported who demonstrated specific food intolerance, and their response to treatment with oral sodium cromoglycate is described.…”

mentioning

confidence: 99%

Food allergy: Response to treatment with sodium cromoglycate

Watson¹,

Timmins²

1979

Archives of Disease in Childhood

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mentioning

confidence: 99%

Food allergy: Response to treatment with sodium cromoglycate

Watson¹,

Timmins²

1979

Archives of Disease in Childhood

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Use of Cromolyn in Combined Gastrointestinal Allergy

Kocoshis¹

1979

JAMA

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A double-blind clinical trial was undertaken to evaluate the efficacy of orally given cromolyn sodium vs that of pacebo in the management of food allergy. Fourteen children, aged 2 to 15 years, with milk allergy and concomitant allergies to one or more foods were given cromolyn or placebo. Eleven had positive intradermal skin reactions or coproantibodies to offending antigens. Treatment was begun while the children were receiving elimination diets; they were challenged with specific antigen only after 48 hours of drug administration. Crossover took place if the initial agent was ineffective. Cromolyn afforded protection in 11 of 13 trials, whereas placebo was effective in only three of nine trials. By chi 2 analysis, the drug's effect was statistically significant.

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Cromolyn Sodium: A Review

1985

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Cromolyn is a white crystalline powder which is poorly absorbed from the gastrointestinal tract. Its therapeutic value lies in its functions as an inhaled or topically applied agent. Cromolyn has been approved in the United States for asthma therapy since 1973. It was marketed at that time as a drug to reduce the corticosteroid requirements of severe asthmatics. It clearly did not live up to that claim. Initial enthusiasm for cromolyn was replaced by disillusionment. In the last few years, investigators have taken another look at cromolyn and have a renewed interest in it. Cromolyn's mechanisms of action remain only partially understood. It appears to block allergic mediator release from certain mast cells. It may also decrease bronchial hyperreactivity. The frequency of drug toxicity at customary dosages is extremely low. Adverse effects tend to be mild, short-lived and without sequelae. Currently, cromolyn is a first line therapy for mild to moderate asthma requiring chronic treatment. It is also of proven efficacy in the treatment of allergic rhinitis, allergic conjunctivitis and vernal keratoconjunctivitis.

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Treatment of Allergy to Cow's Milk

Cited by 14 publications

References 5 publications

Food allergy: Response to treatment with sodium cromoglycate

Food allergy: Response to treatment with sodium cromoglycate

Use of Cromolyn in Combined Gastrointestinal Allergy

Cromolyn Sodium: A Review

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