Treatment of Aged Skin with a pH 4 Skin Care Product Normalizes Increased Skin Surface pH and Improves Barrier Function: Results of a Pilot Study

Blaak, Jürgen; Wohlfart, Rainer; Schürer, Nanna

doi:10.4236/jcdsa.2011.13009

Cited by 30 publications

(36 citation statements)

References 37 publications

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“…However, application in this study was only for a short-term period of 7 days. Interestingly, comparable effects were observed with a pH 4 O/W emulsion after 14 days of application [21]. However, in this study no further decrease after 14 days was observed.…”

Section: Discussionmentioning

confidence: 41%

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

Behm

Kemper

Babilas

et al. 2015

Skin Pharmacol Physiol

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The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.

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Section: Discussionmentioning

confidence: 41%

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

Behm

Kemper

Babilas

et al. 2015

Skin Pharmacol Physiol

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show abstract

“…More research addressing this topic may help affected patients and promote changes in skin hygiene and skin care behavior. For the elderly, who are also known to have elevated pH ss values and often suffer from dry skin, acidic toiletries have already been recommended in the past [15,19,21,22,33]. …”

Section: Discussionmentioning

confidence: 99%

“…These findings have led to the development of acidic skin care products. Several target groups that may profit from these products in particular have been defined in other studies (e.g., elderly, patients with atopic dermatitis, diabetics) [14,15,19,20,21,22]. Prior research of our study group examined the effect of a pH 4 water-in-oil (W/O) emulsion as well as a 10% α-hydroxy acid O/W emulsion on pH ss and pH sc in healthy subjects and diabetics [19,23].…”

Section: Introductionmentioning

confidence: 99%

Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH

Fürtjes

Weiß

Filbry

et al. 2017

Skin Pharmacol Physiol

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Background: Human skin surface has a physiologically acidic pH (pH_ss). In cases of increased pH_ss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pH_ss regeneration and stabilization. Methods: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pH_ss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. Experiment 1: after defining the baseline pH_ss, we alkalized the respective area and measured pH_ss over a duration of 5 h, while applying emulsion every hour. Experiment 2: study subjects used the emulsion twice daily for 1 week. Then, pH_ss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. Results: (1) 5 h after alkalization, the treated arm showed a significantly lower pH_ss than the untreated one (5.87 ± 0.03 vs. 6.05 ± 0.03); (2) after washing, the treated area had a significantly lower pH_ss than controls (6.13 ± 0.03 vs. 6.27 ± 0.05). Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pH_ss.

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“…An increased pH correlates with reduced barrier, integrity/cohesion. In a study it was postulated that long-term acidic skin care (pH 3.5 to pH 4.0) normalizes the increased skin pH of the elderly, improves the integrity of the epidermal barrier and therefore reduces skin problems in these individuals 27 . The pH of our prepared AV blended COL-CS gel was found to be 4.5, which indicates that our prepared gel is perfect to be used as a long term skin care product.…”

Section: Fig 2: Sa-β-gal Positive Nih3t3 Mouse Fibro Blasts Cells (Cmentioning

confidence: 99%

Untitled

2018

IJPSR

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Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals pose health and safety risk on human health. In an effort to produce a promising natural anti-aging agent in contemporary cosmetics, this study has been aimed to formulate an anti-aging gel by blending three biopolymers namely Collagen (COL) 3%w/v, Chitosan (CS) 1.5% w/v and Aloe vera (AV) gel 0.21% w/v. The AV blended COL-CS gel was characterized by spreadability and moisture uptake test, which indicated good spreadability and increased hydrophyllicity of the gel. Cell culture studies on NIH3T3 mouse fibroblasts cells were carried out using senescenceassociated-β-gal [SA-β-gal] as a biomarker. The fibroblasts cells on incubation with AV blended COL-CS gel showed increased proliferation rate and the absence of blue stain indicated that the process of senesce has been reversed. In conclusion, the prepared AV blended COL-CS gel helps in regeneration and rejuvenation of the skin and therefore can be used as a promising anti-aging gel.

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Treatment of Aged Skin with a pH 4 Skin Care Product Normalizes Increased Skin Surface pH and Improves Barrier Function: Results of a Pilot Study

Cited by 30 publications

References 37 publications

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH

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