Treatment of Advanced Metastatic Prostate Cancer Using Molecular-Targeted Therapy: Radioligand Lutetium-177 Prostate-Specific Membrane Antigen

Abstract

This study investigates the predicting factors of the biochemical response and survival of patients with advanced metastatic prostate cancer who underwent therapy with radioligand lutetium-177 ( 177 Lu)prostate-specific membrane antigen (PSMA), often referred to as [ 177 Lu]Lu-PSMA. This study is a review of the previous literature. This study included articles published in the last 10 years in the English language.According to the literature review, treatment with [ 177 Lu]Lu-PSMA has a positive impact on prostatespecific antigen (PSA) within the first cycle and a negative impact on lymph node metastasis. There is a plausible positive impact on PSA after multiple cycles and performance status and a negative impact on visceral metastasis. In conclusion, the reviews show that treatment with [ 177 Lu]Lu-PSMA in patients with castration-resistant prostate cancer is beneficial in reducing PSA and metastasis.