Treatment of Adult T-Cell Leukemia–Lymphoma with a Combination of Interferon Alfa and Zidovudine

Gill, Parkash S.; Harrington, William J.; Kaplan, Mark H.; Ribeiro, Raul C.; Bennett, John M.; Liebman, Howard A.; Bernstein-Singer, Marjorie; Espina, Byron M.; Cabral, Lisa; Allen, Sheila; Kornblau, Steven M.; Pike, Malcolm C.; Levine, Alexandra M.

doi:10.1056/nejm199506293322603

Cited by 343 publications

(212 citation statements)

References 28 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…15 ATL remains of poor prognosis with a median survival time of 13 months in aggressive ATL. 16 Conventional therapies do not seem to prolong survival of patients with ATL, 17 and the development of new therapeutic strategies for ATL is necessary. Because of the low incidence and long latency of ATL, leukemogenesis is thought to be a multistep process.…”

mentioning

confidence: 99%

Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity

Tomita

Toyota

Ishikawa

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Retraction: The following article has been retracted through agreement between the first author and several coauthors, the journal Editor‐in‐Chief, Peter Lichter, and John Wiley & Sons, Ltd.: Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N. (2009). Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐kappaB activity. Int J Cancer; 124 (June (11)): 2607‐2615, published online on 12 JAN 2009 in Wiley Online Library (www.onlinelibrary.wiley.com). After an investigation the retraction has been agreed due to inappropriate duplication of images and overlap with other published work.

show abstract

mentioning

confidence: 99%

Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity

Tomita

Toyota

Ishikawa

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Many polychemotherapy clinical trials were carried out in Japan between 1978 and 1983 [69], and although the CR rate was usually higher in the lymphoma type as compared to acute ATL, the long-term survival was identical. Despite these obstacles recent encouraging results were obtained by allogeneic bone marrow transplantation (alloBMT) [70], combinations of AZT and a-IFN [71][72][73][74], arsenic trioxide and a-IFN [75,76], alltrans-retinoic acid (ATRA) therapy [77][78][79], and the use of radiolabeled anti IL-2R (CD25) antibodies [80,81]. Current therapeutic strategies for the treatment of ATLL have recently been reviewed [82].…”

Section: Clinical Features Of Htlv-i-associated Atl and Atl Lymphomamentioning

confidence: 99%

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

Nicot

2005

Am. J. Hematol.

104

View full text Add to dashboard Cite

Epidemiological studies have demonstrated that the relative percentage of malignant lymphoid proliferations varies widely according to geographical location and ethnic populations. HTLV-I is the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and is also associated with cutaneous T-cell lymphoma (CTCL). However, a definite role of HTLV-I in mycosis fungoides (MF) and/or Sezary syndrome (SS) remains controversial. While most HTLV-I-infected individuals remain asymptomatic carriers, 1-5% will develop ATLL, an invariably fatal expansion of virus-infected CD4 + T cells. This low incidence and the long latency period preceding occurrence of the disease suggest that additional factors are involved in development of ATLL. In this review, diagnosis, clinical features, and molecular pathogenesis of HTLV-I are discussed. Am.

show abstract

“…Antiviral therapy with zidovudine (AZT) and interferon-alpha (IFN-a) in these patients has produced longterm clinical remissions in human trials (Gill et al, 1995;Hermine et al, 1995;Matutes et al, 2001;White et al, 2001). In HTLV-I-infected cells, Tax stimulates endogenous hTERT promoter (Sinha-Datta et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Telomere attrition induces a DNA double-strand break damage signal that reactivates p53 transcription in HTLV-I leukemic cells

Datta

Nicot

2007

Oncogene

View full text Add to dashboard Cite

Persistent inhibition of telomerase induces a severe telomere shortening in human T-cell leukemia virus type-1-infected cells which signals a DNA double-strand break damage response, formation of telomere dysfunction-induced foci and activates the ATM pathway. In turn, activation of ATM and its downstream effectors led to an increased phosphorylation and acetylation on specific residues of p53 known to be involved in transcriptional activation. Disruption of Mdm2-p53 complexes coupled with increased proteasomal degradation of MDMX further enhanced reactivation of p53 transcription, ultimately leading to senescence of tumor cells. Induction of senescence in these T-cells was associated with an increased expression of p21, p16 and activation of GSK3b. Our results support the cancer-aging model and demonstrate that the halt of aging in cancer cells can be reversed through reactivation of p53.

show abstract

Treatment of Adult T-Cell Leukemia–Lymphoma with a Combination of Interferon Alfa and Zidovudine

Abstract: The combination of zidovudine and interferon alfa has activity against adult T-cell leukemia-lymphoma, even in patients in whom prior cytotoxic therapy has failed. This regimen should be evaluated further for its role in the treatment of adult T-cell leukemia-lymphoma.

Cited by 343 publications

References 28 publications

Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity

Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity

Current views in HTLV-I-associated adult T-cell leukemia/lymphoma

Telomere attrition induces a DNA double-strand break damage signal that reactivates p53 transcription in HTLV-I leukemic cells

Contact Info

Product

Resources

About