Treatment of Acute Stanford Type B Aortic Dissection With a Novel Cylindrical Balloon Catheter in Dogs

Endovascular creation of aortic dissection in a swine model with technical considerations

“…In fact, far more dissected length was obtained in our model than in other similar models. 9,17,19 Our method not only rendered the blood flow in the false lumen sufficient and stable, it also contributed to decreasing the risk of aortic rupture, which occurred in two cases (14.3%) in our model. Nevertheless, the incidence of aortic rupture in our study was less common than that in Razavi's study in which dissection was created using an antegrade approach.…”

“…9-20 These models, however, have had certain disadvantages. Thoracotomy and/or laparotomy are usually necessary to create an aortic dissection model [9][10][11][12][13][14][15][16][17][18][19][20] ; however, such invasive surgical procedures are not suitable for use as dissection models for medical treatment. In our model, only endovascular procedures were used, and neither thoracotomy nor laparotomy was required.…”

“…22 Furthermore, small animals such as canines are not suitable for carrying out experiments involving endovascular therapy due to small aortic size. [9][10][11][12][13][14][15]18,20 We used swine with a mean aortic diameter of 10.9 Ϯ 2.9 mm; thus, swine should be considered a suitable model for future studies using endografts.…”

“…Among the surgical attempts used for animal models, [9][10][11][12][13][14][15][16][17][18][19][20] various techniques have been used to create an initial dissection at the proximal site, including elastase infusion, 19 normal saline infusion, 17,20 using an endarterectomy spatula, [10][11][12]14 hand rubbing the initial dissected site to widen the tear, 16 balloon dilatation combined with solution infusion, 18 and increasing the blood pressure after surgery. 10,13 With respect to creating the initial dissection, we developed a new and attractive technique using a modified 10F outer sheath with a 14 G stiffening metallic cannula of the Rösche-Uchida Transjugular Liver Access Set.…”

“…There have been several attempts to create aortic dissection models in animals with surgical procedures; these have certainly contributed to the development of advanced therapies. [9][10][11][12][13][14][15][16][17][18][19][20] However, surgical models have had limitations in the sense of its invasiveness. Another disadvantage is that creating the primary tear from the outer side of the aorta clearly differs from the spontaneous aortic dissection mechanism that occurs from the inner lumen.…”