Treatment of Acute Radiodermatitis with an Oil-in-Water Emulsion Following Radiation Therapy for Breast Cancer

Jensen, Jens‐Michael; Gau, Tanja; Schultze, Jürgen; Lemmnitz, Gunter; Fölster‐Holst, Regina; May, Theodor W.; Abels, Christoph; Proksch, Ehrhardt

doi:10.1007/s00066-011-2224-8

Cited by 32 publications

(27 citation statements)

References 32 publications

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“…Of the 47 studies, 22 studies adequately reported allocation concealment [31,32,35,37,39-41,43,45,47],[50-53,55,56,59,63,68,69,71],[72]. The method used to conceal the allocation sequence was not reported in the remaining studies, thus receiving a judgement of unclear risk of bias for this domain.…”

Section: Resultsmentioning

confidence: 99%

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

et al. 2014

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BackgroundRadiation-induced skin reaction (RISR) is a common side effect that affects the majority of cancer patients receiving radiation treatment. RISR is often characterised by swelling, redness, pigmentation, fibrosis, and ulceration, pain, warmth, burning, and itching of the skin. The aim of this systematic review was to assess the effects of interventions which aim to prevent or manage RISR in people with cancer.MethodsWe searched the following databases up to November 2012: Cochrane Skin Group Specialised Register, CENTRAL (2012, Issue 11), MEDLINE (from 1946), EMBASE (from 1974), PsycINFO (from 1806), CINAHL (from 1981) and LILACS (from 1982). Randomized controlled trials evaluating interventions for preventing or managing RISR in cancer patients were included. The primary outcomes were development of RISR, and levels of RISR and symptom severity. Secondary outcomes were time taken to develop erythema or dry desquamation; quality of life; time taken to heal, a number of skin reaction and symptom severity measures; cost, participant satisfaction; ease of use and adverse effects. Where appropriate, we pooled results of randomized controlled trials using mean differences (MD) or odd ratios (OR) with 95% confidence intervals (CI).ResultsForty-seven studies were included in this review. These evaluated six types of interventions (oral systemic medications; skin care practices; steroidal topical therapies; non-steroidal topical therapies; dressings and other). Findings from two meta-analyses demonstrated significant benefits of oral Wobe-Mugos E for preventing RISR (OR 0.13 (95% CI 0.05 to 0.38)) and limiting the maximal level of RISR (MD -0.92 (95% CI -1.36 to -0.48)). Another meta-analysis reported that wearing deodorant does not influence the development of RISR (OR 0.80 (95% CI 0.47 to 1.37)).ConclusionsDespite the high number of trials in this area, there is limited good, comparative research that provides definitive results suggesting the effectiveness of any single intervention for reducing RISR. More research is required to demonstrate the usefulness of a wide range of products that are being used for reducing RISR. Future efforts for reducing RISR severity should focus on promising interventions, such as Wobe-Mugos E and oral zinc.

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Section: Resultsmentioning

confidence: 99%

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

et al. 2014

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“…Table 3 lists the randomized studies on the prevention of acute radiation skin reactions in patients with breast cancer receiving radiotherapy in last 5 years. 4,[17][18][19][20][21][22][23][24][25][26][27][28] Randomized controlled studies have generated mostly negative results for use of skin care products in preventing or treating radiation dermatitis. Remarkably, patients receiving topical corticosteroids (mometasone furoate and betamethasone) during radiotherapy might experience reduced acute skin toxicity compared with placebo or moisturizing creams according to the result of three doubleblind studies with a larger population.…”

Section: Discussionmentioning

confidence: 99%

Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy

Zhao¹,

Zhu²,

Li³

et al. 2016

BJR

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“…Acute effects begin with erythema, edema, pigment changes, and depilation. Even though, histological analyses of irradiated skin show hyperproliferation of the epidermis and thickening of the stratum corneum; transepiderml water loss (TEWL), a measure for skin barrier integrity, is significantly increased (Jensen et al ., 2011; Schmuth et al ., 2001). Severe radiation injury results in complete loss of the epidermis and persistent fibrinous exudates and edema.…”

Section: Current Understanding: Perception Of Radiation Skin Injurymentioning

confidence: 99%

“… * Data compiled from (Elliott et al ., 2006; Holler et al ., 2009; Jensen et al ., 2011; Okunieff et al ., 2006; Pommier et al ., 2004; Ryan et al ., 2011; Xiao et al ., 2006) …”

Section: Figurementioning

confidence: 99%

Ionizing Radiation: The Good, the Bad, and the Ugly

Ryan

2012

Journal of Investigative Dermatology

377

371

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Skin changes from ionizing radiation have been scientifically documented since 1902 (Hymes et al., 2006). Ionizing radiation is a widely accepted form of treatment for various types of cancer. Despite the technological advances, radiation skin injury remains a significant problem. This injury, often referred to as radiation dermatitis, occurs in about 95% of patients receiving radiation therapy for cancer and ranges in severity from mild erythema to moist desquamation and ulceration (McQuestion, 2011; Salvo et al., 2010). Ionizing radiation is not only a concern for cancer patients, but also a public health concern due to the potential for and reality of a nuclear and/or radiological event. Recently, the United States has increased efforts to develop medical countermeasures to protect against radiation toxicities from acts of bioterrorism, as well as cancer treatment. Management of radiation dermatitis would improve the therapeutic benefit of radiation therapy for cancer and potentially the mortality expected in any “dirty bomb” attack (Benderitter et al., 2010; Muller and Meineke, 2010). Currently, there is no effective treatment to prevent or mitigate radiation skin injury. This review summarizes “the good, the bad and the ugly” of current and evolving knowledge regarding mechanisms of and treatments for radiation skin injury.

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Treatment of Acute Radiodermatitis with an Oil-in-Water Emulsion Following Radiation Therapy for Breast Cancer

Abstract: Treatment of radiodermatitis with an oil-in-water emulsion was well tolerated, enhanced stratum corneum hydration, improved clinical indicators, and provided relief from itching.

Cited by 32 publications

References 32 publications

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy

Ionizing Radiation: The Good, the Bad, and the Ugly

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