Treatment of acute Pneumocystis carinii pneumonia with corticosteroids in a patient with acquired immunodeficiency syndrome

Gallacher, Bernard P.; Gallacher, William N.; MacFadden, Douglas

doi:10.1097/00003246-198901000-00019

Cited by 6 publications

(1 citation statement)

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“…Several studies have demonstrated a possible role of intravenous corticosteroids in adjunctive therapy in cases with acute life-threatening respiratory failure secondary to PCP. It was also speculated in some studies that adjunctive corticosteroid therapy might obviate the use of mechanical ventilation (Gallacher et al, 1989). The outcome of patients with corticosteroid therapy and the role of mechanical ventilation have yet to be examined.…”

Section: Resultsmentioning

confidence: 99%

Management of Pneumocystis carinii pneumonia in patients with conventionally caused immune suppression.

Katsumata

Kohno

Koga

et al. 1991

Jap. J. Trop. Med. Hyg.

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Ten non-AIDS patients with Pneumocystis carinii pneumonia were studied. While the 2 patients with adult T cell leukemia had longer prodromes, the other 8 patients had acute onset. At presentation a chest radiograph revealed an abnormal bilateral diffuse shadow in all cases. In 8 patients, diagnostic material was obtained by transbronchiallung biopsy and/or bronchoalveolar lavage, and in 2 patients at postmortem. At the time of diagnosis the serum lactate dehydrogenase value was much higher than prior to the acute illness, and the AaD0 2 gradient was highly increased: These appear to be useful as markers for an initial diagnosis. Other opportunistic organisms were isolated in 5 patients. The concomitant use of pentamidine and cotrimoxazole was relatively well tolerated, but with a high incidence of treatment failure. Corticosteroids appeared to be effective as an adjunctive therapy.

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Section: Resultsmentioning

confidence: 99%