Treatment of acquired reactive perforating collagenosis with 308-nm excimer laser

Matsui, Akinobu; Nakano, Hajime; Aizu, Takayuki; Sawamura, Daisuke

doi:10.1111/ced.12891

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Evidence level: 5 Consensus level: 4.22 Recommendation level: C1 Commentary: Three case reports noted that UV therapy was effective for acquired reactive perforating collagenosis, [17][18][19] and one case series reported the same as well. 20 The recommendation level C1 was set based on the evidence level and consensus level.…”

Section: Cq4: Is Ultraviolet (Uv) Therapy Effective For Acquired Reac...mentioning

confidence: 99%

Clinical practice guide for the treatment of perforating dermatosis

Kawakami

Akiyama

Ishida‐Yamamoto

et al. 2020

The Journal of Dermatology

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Perforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various skin materials. Four classical forms of primary perforating dermatosis have been described, where the transepidermal elimination mechanism represents the hallmark of the disease: acquired reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle's disease and perforating folliculitis. Acquired reactive perforating collagenosis presents with transepidermal elimination of collagen fibers. Elastosis perforans serpiginosum presents with the elimination of elastic fibers. Kyrle's disease presents with transepidermal elimination of abnormal keratin. In perforating folliculitis, it is the content of the follicle. We established diagnostic criteria and severity classification. In addition, the Japanese guideline for treatment of perforating dermatoses was updated using the Medical Information Network Distribution Service (MINDS) methodology. The guideline is based on a systematic published work review completed from 1989 to 2019, and on a formal consensus and approval process. Most medical published work on the treatment is limited to individual case reports and small series of patients. The guideline covers treatment options considered relevant by the expert panel and approved in Japan at the time of the consensus conference.

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Section: Cq4: Is Ultraviolet (Uv) Therapy Effective For Acquired Reac...mentioning

confidence: 99%

Clinical practice guide for the treatment of perforating dermatosis

Kawakami

Akiyama

Ishida‐Yamamoto

et al. 2020

The Journal of Dermatology

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“…In the literature and treatment guidelines, phototherapy has been recognized as one of the effective treatment options for APD [ 37 , 38 ]. Mechanisms of antipruritic effects of phototherapy include mast cell suppression, and reduced epidermal nerves decreasing TGF-β expression, which is important in APD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center

Edek,

Aypek,

Öğüt

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions. Objectives: In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options. Methods: This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital. Results: A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents. Conclusions: Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.

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“…It is widely recognized that this dermatosis occurs most commonly among those with systemic disorders, especially diabetes mellitus and renal failure (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). It is worth noting that despite its rarity, a 2-11% incidence of APD onset has been reported in patients receiving maintenance dialysis for end stage renal disease (13).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognosis of acquired perforating dermatosis: A case report

et al. 2020

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Acquired perforating dermatosis (APD) is an uncommon skin disease characterized by umbilicated hyperkeratotic lesions, and involves the transepidermal elimination of dermal components, including collagen and elastic fibers. The disease can affect patients with systemic disorders, especially those with chronic renal failure or diabetes mellitus. The current paper described four cases of patients with APD and investigated the clinical characteristics and prognosis of APD, as well as its possible link with systemic disorders. In each of the four cases, the patient had systemic disorders before the onset of APD, three had concomitant renal and thyroid disorders and one had hepatocirrhosis secondary to chronic hepatitis C. The results of the present study showed that APD occurred after the transient worsening of the original systemic disease. Furthermore, it was revealed that dermatosis symptoms were alleviated upon remission of the original systemic disorder, without specific dermatological treatment. Dermatosis symptoms improved in all four patients, indicating that the management of the associated systematic diseases was essential for the successful clinical outcomes of APD.

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Treatment of acquired reactive perforating collagenosis with 308-nm excimer laser

Cited by 6 publications

References 4 publications

Clinical practice guide for the treatment of perforating dermatosis

Clinical practice guide for the treatment of perforating dermatosis

Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center

Clinical characteristics and prognosis of acquired perforating dermatosis: A case report

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