Treatment of acne with oral isotretinoin in patients with cystic fibrosis

Perera, Eshini; Massie, John; Phillips, Roderic J

doi:10.1136/adc.2008.156406

Cited by 7 publications

(9 citation statements)

References 7 publications

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“…Our literature review revealed 11 previous cases of patients with CF treated with isotretinoin for acne (TABLE 1) [2,6,7]. Including Patients 1 and 2, all 13 patients experienced significant improvement in their acne.…”

Section: Discussionmentioning

confidence: 96%

“…Cystic fibrosis (CF) affects approximately one in every 3,700 U.S. births [1] and the disease is the most common severe autosomal recessive disorder in Caucasians [2]. A mutation in the cystic fibrosis transmembranes regulator (CFTR) gene causes a defect in electrolyte transport in exocrine epithelia, leading to viscous secretions that can obstruct the lungs, pancreas, and gastrointestinal tract [3].…”

Section: Introductionmentioning

confidence: 99%

“…A mutation in the cystic fibrosis transmembranes regulator (CFTR) gene causes a defect in electrolyte transport in exocrine epithelia, leading to viscous secretions that can obstruct the lungs, pancreas, and gastrointestinal tract [3]. Clinical features include chronic pulmonary infections and pancreatic insufficiency [2].…”

Section: Introductionmentioning

confidence: 99%

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Isotretinoin therapy for the treatment of acne in patients with cystic fibrosis: a case series and review of the literature

Bari

Paravar

2016

Dermatology Online Journal

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Isotretinoin therapy for the treatment of acne in patients with cystic fibrosis: a case series and review of the literature

Bari

Paravar

2016

Dermatology Online Journal

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“…Isotretinoin administered to patients with severe cystic acne, has marked effects on sebum production and composition in the sebaceous glands (Al Hallak and Zouain, 2009). Oral isotretinoin is clearly more effective than oral antibiotics in acne of all grades of severity (Dréno et al, 2006;Perera et al, 2009). There is strong evidence to show that isotretinoin significantly reduces the psychological problems associated with acne (Misery, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Ahmadv¹

2011

Afr. J. Pharm. Pharmacol.

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The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Fortyfour patients, with severe acne or moderate acne (age mean 23 6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin.

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“…4 Oral isotretinoin is clearly more effective than the oral antibiotics in acne and significantly reduces the lesions. 5 Isotretinoin is chemically related to retinoid vitamin A, a fat soluble vitamin stored in high concentration in liver. 6 The exact mechanism of action of isotretinoin is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Study of Lipid Profile changes in Acne vulgaris on intermittent low dose Isotretinoin

Leelambika¹,

Sarkar²

2016

JIMD

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Abstract:Acne vulgaris is a common skin disease characterized by comedones, inflammatory lesions, secondary dispigmentation and scarring with a large impact on quality of life. There has been much debate as to whether liver function tests and lipids should be monitored while on therapy. The objective of the study is to evaluate the lipid profile changes in patients with moderate to severe acne on oral intermittent low dose isotretinoin therapy. Setting: Dermatology outpatient clinics, MIMS, Mandya. We included the 50 patients diagnosed with moderate to severe acne. All patients were treated with low dose isotretinoin and followed up in our outpatient clinics for 20 weeks. Patients were subjected to an interview questionnaire which included data on age, gender, previous treatment and liver enzymes. Blood analysis were repeated in the follow-up visits baseline, 4, 8,12,16, 20 weeks. Total cholesterol, triglycerides, HDL, LDL of 50 patients aged 15-40 years receiving isotretinoin for moderate to severe acne were monitored before, during and every month interval for 4 months. There was a statistically significant increase in the levels of total cholesterol, triglycerides, LDL with the decrease in the HDL level when compared with the baseline. The results in the study showed that the use of oral isotretinoin for the treatment of acne resulted in altered total cholesterol, triglycerides, LDL and HDL but the increase in the parameters is mild so as to not interrupt the treatment. Our study show that intermittent isotretinoin therapy has not much effect on the lipid profile and the adverse effects can be treated without interrupting the treatment.

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Treatment of acne with oral isotretinoin in patients with cystic fibrosis

Cited by 7 publications

References 7 publications

Isotretinoin therapy for the treatment of acne in patients with cystic fibrosis: a case series and review of the literature

Isotretinoin therapy for the treatment of acne in patients with cystic fibrosis: a case series and review of the literature

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Study of Lipid Profile changes in Acne vulgaris on intermittent low dose Isotretinoin

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