Treatment of Acanthosis Nigricans With Oral Isotretinoin

Katz, Ronald A.

doi:10.1001/archderm.1980.01640250112027

Cited by 39 publications

(8 citation statements)

References 7 publications

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“…75 Topical tretinoin or oral isotretinoin may reduce and even eliminate AN. 76,77 Retinoids exert keratolytic effects and enhance desquamation of hyperpigmented epidermal cells by stimulating mitosis and the shedding of desmosomes. 76 Combination therapy with 0.05% topical tretinoin and 12% ammonium lactate has shown efficacy in treating obesity-associated AN.…”

Section: Differential Diagnosismentioning

confidence: 99%

Juvenile acanthosis nigricans

Sinha¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

117

136

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Section: Differential Diagnosismentioning

confidence: 99%

Juvenile acanthosis nigricans

Sinha¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

117

136

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“…Others have reported the same results [28][29][30]. Katz [31 ] treated a patient with AN with oral isotretinoin in increasing doses of 0.5 mg/kg/week; by the sixth week, when the dose had reached 3 mg/kg/day, the skin had flat tened. and its color had returned to normal.…”

Section: Discussionmentioning

confidence: 61%

Acanthosis nigricans Caused by Nicotinic Acid: Case Report and Review of the Literature

Stals

Vercammen²,

Peeters³

et al. 1994

Dermatology

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Drug-induced acanthosis nigricans has been reported in the literature. We present a patient with familial combined hyperlipidemia who developed nicotinic-acid-induced acanthosis nigricans. The literature on the cutaneous side effects of nicotinic acid as well as on the medications that can cause acanthosis nigricans is reviewed. Some hypotheses on the pathogenesis of nicotinic-acid-induced acanthosis are presented.

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“…The patient received a maintenance dose because discontinuation of the therapy resulted in quickly recurrent lesions. Topical tretinoin and calcipotriol have also been used with some limited success [131,132].…”

Section: Acanthosis Nigricansmentioning

confidence: 99%