Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Zhang, J; Chen, Z; Xie, Lin; Zhao, Hongyan; Fu, Chao; Chen, G; Zhou, Hao; Wang, L; Li, W

doi:10.1590/1414-431x20165712

Cited by 5 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…In China, a case of subdural empyema complicated by intracerebral abscess due to Brucella infection was effectively treated with antibiotic therapy (ceftriaxone, doxycycline, rifapentine) [ 108 ]. In line with this, several reports suggested the combination therapy of doxycycline and rifampicin for six weeks is enough to eradicate Brucella infection, as well as associated complications [ 46 , 109 , 110 , 111 ].…”

Section: Treatment Of Brucellosismentioning

confidence: 99%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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Brucellosis is one of the most common contagious and communicable zoonotic diseases with high rates of morbidity and lifetime sterility. There has been a momentous increase over the recent years in intra/interspecific infection rates, due to poor management and limited resources, especially in developing countries. Abortion in the last trimester is a predominant sign, followed by reduced milk yield and high temperature in cattle, while in humans it is characterized by undulant fever, general malaise, and arthritis. While the clinical picture of brucellosis in humans and cattle is not clear and often misleading with the classical serological diagnosis, efforts have been made to overcome the limitations of current serological assays through the development of PCR-based diagnosis. Due to its complex nature, brucellosis remains a serious threat to public health and livestock in developing countries. In this review, we summarized the recent literature, significant advancements, and challenges in the treatment and vaccination against brucellosis, with a special focus on developing countries.

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Section: Treatment Of Brucellosismentioning

confidence: 99%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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“…Inadequate nutrition weakens immune defenses, increasing infection risks [11]. Furthermore, nutritional health is vital during treatment and recovery, with nutritional de cits potentially delaying wound healing, impeding neurological recovery, and prolonging the recovery process [12]. Such de ciencies can negatively impact patient lifespan, and quality of life, and impose signi cant economic costs [13].…”

Section: Introductionmentioning

confidence: 99%

Geriatric Nutritional Risk Index has a Prognostic value for Recovery Outcomes in Elderly Patients with Brain Abscess

Pei,

Zhang,

Jiang

et al. 2024

Preprint

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Background: The Geriatric Nutritional Risk Index (GNRI) is a straightforward and objective tool for nutritional screening in elderly patients and has been demonstrated to possess prognostic predictive value in several diseases. Nonetheless, there is a lack of research on the nutritional risk associated with brain abscess in the elderly. This study aimed to evaluate the prevalence of nutritional risk among these patients by GNRI and to investigate its potential prognostic value for clinical outcomes. Methods: From August 2019 to April 2023, 100 elderly patients diagnosed with brain abscess were enrolled in the study. The collected data encompassed age, gender, body mass index (BMI), smoking and alcohol consumption history, number of comorbidities, length of hospital stay (LOS), serum albumin and C-reactive protein (CRP) levels at admission and calculated the GNRI, the Glasgow outcome scale (GOS) score 6 months post-discharge. A GOS score of 5 was considered indicative of a good recovery, whereas scores ranging from 1 to 4 were classified as poor recovery. Results: The prevalence of malnutrition risk among elderly patients with brain abscesses was found to be 48% according to GNRI. Compared to those without nutritional risk, patients at risk exhibited significantly higher post-admission C-reactive protein (CRP) levels (P=0.017), a greater number of comorbidities (P<0.001), and elevated age-adjusted Charlson Comorbidity Index (aCCI) scores (P<0.001). Spearman correlation analysis revealed a negative correlation between GNRI scores and CRP levels, the number of comorbidities, and aCCI scores (Spearman's ρ=-0.291, -0.284, and -0.310, respectively), and a positive correlation with Glasgow Outcome Scale (GOS) scores (Spearman's ρ=0.624, P<0.001). Multivariate logistic regression analysis indicated that lower GNRI values in these patients were associated with reduced GOS levels (OR = 0.826, 95% CI: 0.775-0.880). Furthermore, receiver operating characteristic (ROC) analysis identified a GNRI threshold of 97.50 for predicting poor recovery, with a sensitivity of 90.57% and a specificity of 87.23%. Conclusions: Elderly brain abscess patients exhibited a high malnutrition risk. GNRI showed an important predictive value for recovery in elderly patients, which could be helpful in clinical intervention and rehabilitation.

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Neurobrucellosis

Dudal¹,

Chrétien²,

Jouvion³

2020

Infections of the Central Nervous System

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Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Cited by 5 publications

References 13 publications

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

Geriatric Nutritional Risk Index has a Prognostic value for Recovery Outcomes in Elderly Patients with Brain Abscess

Neurobrucellosis

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