Treatment of 60 Cases of Gouty Arthritis with Modified Simiao Tang

Renbin, Qiu; Shen, Ruizi; Dejiu, Lin; Chen, Yuan-Lin; Hongping, Ye

doi:10.1016/s0254-6272(08)60023-0

Cited by 28 publications

(27 citation statements)

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“…The trial of Shi et al compared three different MSD with indomethacin and benzbromarone, and we just extracted the data of Group III and control group [6]. In the urate-lowering therapies group, we searched three studies [7, 17, 23]. In the combined therapy subgroup, we searched eleven studies [6, 12, 19, 21, 25, 27–32].…”

Section: Resultsmentioning

confidence: 99%

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The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta‐Analysis

Liu

Huang

Wen

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials (RCTs) comparing the effects of MSD and anti-inflammation medications and/or urate-lowering therapies in patients with gouty arthritis were included. In comparison with anti-inflammation medications, urate-lowering therapies, or coadministration of anti-inflammation medications and urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid (p < 0.00001, mean difference = −90.62, and 95% CI [−128.38, −52.86]; p < 0.00001, mean difference = −91.43, and 95% CI [−122.38, −60.49]; p = 0.02, mean difference = −40.30, and 95% CI [−74.24, −6.36], resp.). Compared with anti-inflammation medications and/or urate-lowering therapies, MSD monotherapy significantly decreased ESR (p < 0.00001; mean difference = −8.11; 95% CI [−12.53, −3.69]) and CRP (p = 0.03; mean difference = −3.21; 95% CI [−6.07, −0.36]). Additionally, the adverse effects (AEs) of MSD were fewer (p < 0.00001; OR = 0.08; 95% CI [0.05, 0.16]). MSD are effective in the treatment of gouty arthritis through anti-inflammation and lowering urate. However, the efficacy of MSD should be estimated with more RCTs.

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Section: Resultsmentioning

confidence: 99%

“…All of the trials were originated from China. Two studies were published in English [6, 7], while 22 studies were published in Chinese. All of the RCTs were conducted as single-centre trials.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta‐Analysis

Liu

Huang

Wen

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…A number of animal experiments reported that TCM showed hypouricemic effects [28, 29] and 2 WHP series formulae [14, 16, 17] lowered the uric acid levels by diverse mechanisms. In a systematic review published in 2013, “25 out of 41 trials, involving 23 different herbal prescriptions, Li, et al, found statistical significance in lowering the serum uric acid level.” However, the authors admitted that the evidence was not decent due to “low quality of included trials” [30].…”

Section: Discussionmentioning

confidence: 99%

“…The authors concluded that modified 4WHP could “significantly improve the symptoms and signs of gouty arthritis and decrease the levels of UA and CRP. It is good for gouty arthritis” [14]. …”

Section: Introductionmentioning

confidence: 99%

“…Published literature also suggested that gypsum (Pinyin Name: Shi Gao; Latin Name: Gypsum Fibrosum) played an important role for hyperuricemia in gout patients [15–17]. Generally, current clinical evidence concerning TCM for gout is methodologically problematic [8, 10, 13, 14]. We decided to put the 2WHP and other TCM together to create a new formula, i.e.…”

Section: Introductionmentioning

confidence: 99%

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“Yellow-dragon Wonderful-seed Formula” for hyperuricemia in gout patients with dampness-heat pouring downward pattern: a pilot randomized controlled trial

Deng³

et al. 2018

Trials

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BackgroundIn Traditional Chinese Medicine (TCM) theories, the typical clinical manifestations of gout are attributed to the “dampness-heat pouring downward.” Therefore, TCM practitioners always consider prescribing the formulae which are believed to clear heat and drain dampness for the management of gout. This clinical trial aims: (1) to determine the hypouricemic effect of “Yellow-dragon Wonderful-seed Formula” (YWF) decoction in gout patients with dampness-heat pouring downward pattern and (2) to determine if gypsum could provide additional significant benefits to YWF.MethodsA total of 72 hyperuricemic individuals with gout and dampness-heat pouring downward pattern were included with 62 of them completing the trial. Participants were randomly assigned to the YWF group, the YWF + gypsum group, or the allopurinol group. YWF and YWF + gypsum decoctions were orally administered for four weeks. Allopurinol was also orally administered for four weeks as the active control. Serum uric acid (sUA) level was the primary outcome measure. Urine urate level, scores on the SF-36 scale, erythrocyte sedimentation rate (ESR), X ray film, and C reactive protein (CRP) level were the secondary outcome measures.ResultsCompared with the values at week 0, YWF and YWF + gypsum did not significantly decrease the sUA level at each weekend reading. YWF, YWF + gypsum, and allopurinol decreased the urine urate levels and there were significant differences between the YWF group and the YWF + gypsum group. All the changes in the eight structures of SF-36 during the intervention period were not significantly different among the three groups and there was no significant difference in the CRP level among the three groups at each weekend reading.ConclusionsYWM, which modified on the basis of Two Wonderful Herbs Powder (2WHP), does not show significant hypouricemic effect. There is a possibility that Gypsum Fibrosum may provide additional effects to YWF in decreasing the urine urate levels but cannot add benefits to YWF in other outcome measures.Trial registrationChinese Clinical Trial Registry, ChiCTR-TRC-12001933. Registered on 10 February 2012.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2917-8) contains supplementary material, which is available to authorized users.

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