Treatment of 29 patients with bulky squamous cell carcinoma of the cervix with simultaneous cisplatin, 5-fluorouracil, and split-course hyperfractionated radiation therapy

Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer

“…14,43 Many combinations of cisplatin have been studied in phase 2 trials of patients with cervical cancer. [44][45][46][47][48][49][50][51] In a phase 3 trial conducted by the Gynecologic Oncology Group, 388 patients were randomly assigned to receive radiotherapy and concomitant chemotherapy either with cisplatin and fluorouracil or with hydroxyurea (Whitney CW: unpublished data); the two-drug regimen improved survival (relative risk of death, 0.74; 95 percent confidence interval, 0.58 to 0.95). In the phase 3 study by Morris et al, 52 whose results are reported in this issue of the Journal, radiotherapy in combination with treatment with cisplatin and fluorouracil significantly improved the rates of disease-free survival and overall survival among women with stage IB through IVA cervical cancer.…”

Surgery alone or surgery with a combination radiation or chemoradiation for management of patients with bulky-stage IB2 cervical carcinoma

“…Following the results from studies indicating the benefits of this treatment modality (20,21) , combined postoperative chemotherapy and radiation were initiated for patients with high-risk factors including nodal metastases, parametrial involvement, and deep stromal invasion. An average of 5 weekly courses of cisplatin (40 mg/m 2 ) and 5-fluorouracil (500 mg/m 2 ) chemotherapy were administered.…”