Treatment of 100 chronic thalassemic leg wounds by plasma‐rich platelets

Afradi, H; Saghaei, Yassaman; Kachoei, Zohre A.; Babaei, Vahid; Teimourian, P.D Shahram

doi:10.1111/ijd.13443

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…After 100 chronic thalassemic leg wounds were treated successfully with PRP gel, its uses were expanded further. 98 When considering the potential benefits of PRP as an adjunctive therapy, the aggressive debridement used to treat wound infections should be considered. 99 Basic research and clinical studies have demonstrated that topical application of PRP is a useful auxiliary therapy for wound infections.…”

Section: Treatment For Hidradenitis Suppurativamentioning

confidence: 99%

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Zhang

Guo

Kuss

et al. 2019

Tissue Engineering Part B: Reviews

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The management and treatment of tissue infection, especially chronic infection, represents a significant challenge. Application of autologous platelet-rich plasma (PRP) has emerged as a promising adjunct therapy for facilitating the healing of surgical wounds and tissue injuries. PRP is extracted from whole blood using a sequential centrifugation technique and when activated, can release a vast array of antimicrobial proteins, cytokines, and growth factors. These bioactive molecules are responsible for the ability of PRP to kill pathogens, resolve necrotic tissue, and promote wound healing. PRP is emerging as a useful supplement to prevent postoperative infection and treat chronic wound or bone infections. PRP displays a synergistic effect with antibiotics, which provides unique advantages when treating antibiotic-resistant bacteria. This review will describe the method for PRP preparation and its antibacterial properties, as well as discuss both preclinical in vivo results and evidence from clinical practice of PRP use for the treatment of wound and bone infections.

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Section: Treatment For Hidradenitis Suppurativamentioning

confidence: 99%

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Zhang

Guo

Kuss

et al. 2019

Tissue Engineering Part B: Reviews

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“…Recently research has shown that 100 chronic thalassemic leg wound were treated by PRP gel and wound size reduction was observed after 4 weeks [4]. Our patient received both autologous PRP subcutaneously and gel topically followed by an optimized diet.…”

Section: Discussionmentioning

confidence: 92%

“…The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, usage of moisture dressings, and offloading high pressure from the wound bed [2]. Cumulative studies have found that autologous platelet concentrate with growth factors or platelet-rich plasma (PRP) may accelerate wound healing [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The topical use of hemocomponents appeared to have a key role in regenerative medicine [6]. Since fifty's, autologous PRP has been used in orthopaedic surgeries and it was first reported in the mid-1980s [7] while PRP gel was later applied to stimulate wound healing in advanced treatment for both chronic and acute wounds [4]. Normal molecular and cellular wound healing process are induced by the effect of the PRP gel which contains a high concentration of thrombocytes, the alpha granules of platelets and platelet-released growth factors including molecules such as platelet-derived growth factor, vascular endothelial growth factor-b and transforming growth factor by stimulating cell proliferation and differentiation resulting in tissue formation [8,9].…”

Section: Introductionmentioning

confidence: 99%

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A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet

Bolouri¹,

Hajimirsadeghi²

2017

Dermatol Case Rep

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The underlying pathomechanisms of delayed wound healing in patients with diabetes mellitus is still a frequent and very severe problem. From a holistic point of view however, contemporary management of chronic wounds attempts to improve natural healing and individualization of treatment. Herein, we report an effective usage of platelet-rich plasma (PRP), both subcutaneously and topically, in combination with an optimized glycemic control diet in a chronic and nonhealing wound. Over 26 weeks, a patient diagnosed with diabetes mellitus had received multiple therapies in attempt to heal a severe leg wound. The introduction to PRP therapy and the daily usage of the PRP gel topically led to an approximately 30% reduction in wound size over 12 days. Optimization of the patient's diet was eventually added to the treatment protocol after seeing the first improvement in wound healing. A weight loss was observed during the treatment period from 105 kg pre-treatment to 88 kg post-treatment, respectively. The prompt and promising outcome of this protocol indicates hope for the patients with chronic wounds and the urge of the further studies with holistic approaches.

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“…62 PRP has been recently used also with local microinjections in the cure of nonhealing ulcers. 63 Trapasso and colleagues 64 reported the excellent result of the treatment with platelet-derived GFs and noncultured autologous cell suspension collected by a single-use device in a chronic vasculitic ulcer.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

Biologics in Microangiopathic Wounds

Papi¹,

Papi

2018

The International Journal of Lower Extremity Wounds

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Pathogenetically, we can distinguish 2 main groups of microangiopathic ulcers (MUs): (1) ulcers due to inflammatory microangiopathy, mainly including cutaneous small and medium vessel vasculitis (VS), pyoderma gangrenosum (PG), and connective tissue disease (CTD), and (2) ulcers due to occlusive microangiopathy. The group of microangiopathic occlusive ulcers is more heterogeneous and includes very poorly understood disturbances (such as livedo vasculopathy and calciphylaxis), still-debated ulcerative diseases (such as hypertensive ulcers), recently described iatrogenic ulcers (ie, during hydroxyurea therapy), ulcers due to cryoprotein deposition, ulcers linked to clot formation (ie, antiphospholipid antibodies) or microembolization (ie, cholesterol emboli and injected substances), and metabolic anomalies. These conditions can induce thromboses or anatomo-functional occlusion of cutaneous microvessels (Figures 1-3). A consistent number of inflammatory MUs are the result of skin necrosis due to a VS. VS is an immunologically mediated angiocentric inflammation, characterized by neutrophils and lymphomonocyte infiltration of the vessel wall, which induces fibrinoid necrosis, reduction of blood supply, and ischemia. The result may be frequently a chronic ulcer

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Treatment of 100 chronic thalassemic leg wounds by plasma‐rich platelets

Abstract: This study will help extrapolation of the use of PRP for at least thalassemic leg wound treatment.

Cited by 14 publications

References 25 publications

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet

Biologics in Microangiopathic Wounds

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