Treatment non-adherence in teenage and young adult patients with cancer

Kondryn, Helena; Edmondson, C.; Hill, Jonathan; Eden, Tim

doi:10.1016/s1470-2045(10)70069-3

Cited by 135 publications

(159 citation statements)

References 54 publications

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“…Nonadherence to recommended treatment and follow-up care contributes to poor clinical outcomes in AYA patients with cancer. 71,72 Failure to keep up with appointments can lead to delayed identification of side effects, complications, or secondary cancers.…”

Section: Adherence To Treatmentmentioning

confidence: 99%

“…Available evidence from clinical trials that have included AYA patients with leukemia and lymphoma suggests that a substantial portion of AYA patients with cancer (27%-63%) have difficulties adhering to their oral treatment regimens. 71,72 Nonadherence to other components of cancer treatment (eg, failure to keep appointments for treatment or follow-up, refusing medical examinations, failing to prepare for procedures or therapy) was also identified in AYA patients. Treatment nonadherence in clinical trials can also interfere with adequate evaluation of the efficacy of a given treatment regimen, which in turn can invalidate the results of a clinical trial.…”

Section: Adherence To Treatmentmentioning

confidence: 99%

“…71,72 • Modify treatment protocol (eg, simplify dosing schedule, change timing and frequency of medication or method of administration), when medically possible, to fit into an AYA patient's lifestyle and normal activities. 71,72 • Provide access to systematic and standardized symptom management for side effects related to cancer treatment. 71,72 See the NCCN Guidelines for Supportive Care (available at www.NCCN.…”

Section: Nccn Recommendations To Promote Adherencementioning

confidence: 99%

“…71,72 • Provide access to systematic and standardized symptom management for side effects related to cancer treatment. 71,72 See the NCCN Guidelines for Supportive Care (available at www.NCCN. org).…”

Section: Nccn Recommendations To Promote Adherencementioning

confidence: 99%

See 3 more Smart Citations

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Coccia¹,

Pappo²,

Beaupin³

et al. 2018

J Natl Compr Canc Netw

253

194

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Section: Adherence To Treatmentmentioning

confidence: 99%

Section: Adherence To Treatmentmentioning

confidence: 99%

Section: Nccn Recommendations To Promote Adherencementioning

confidence: 99%

Section: Nccn Recommendations To Promote Adherencementioning

confidence: 99%

See 2 more Smart Citations

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Coccia¹,

Pappo²,

Beaupin³

et al. 2018

J Natl Compr Canc Netw

253

194

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“…Patient adherence is a crucial factor contributing to the efficacy of a therapeutic regimen [1] . Despite the dangerous nature of paediatric cancers, 50%-55% of chronically ill paediatric patients are non-adherent [2,3] and 10%-50% of cancer-sick children fail to adhere to the oral medication regimen [1,4] .…”

Section: Introductionmentioning

confidence: 99%

Adherence to medication: A nation-wide study from the Children’s Cancer Hospital, Egypt

Malla

Helm²,

Wilderäng³

et al. 2013

WJP

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AIM:To investigate adherence to medical regimen and predictors for non-adherence among children with cancer in Egypt. METHODS:We administered two study specific questionnaires to 304 parents of children diagnosed with cancer at the Children's Cancer Hospital in Cairo, Egypt, one before the first chemotherapy treatment and the other before the third. The questionnaires were translated to colloquial Egyptian Arabic, and due, to the high illiteracy level in Egypt an interviewer read the questions in Arabic to each parent and registered the answers. Both questionnaires consisted of almost 90 questions each. In addition, a Case Report Form was filled in from the child's medical journal. The study period consisted of 7 mo (February until September 2008) and we had a participation rate of 97%. Descriptive statistics are presented and Fisher's exact test was used to check for possible differences between the adherent and non-adherent groups. A P -value below 0.05 was considered significant. Software used was SAS version 9.3 for Windows (SAS Institute Inc., Cary, NC, United States). RESULTS:Two hundred and eighty-one (90%) parents answered the second questionnaire, regarding their child's adherence behaviour. Approximately two thirds of the children admitted to their third chemotherapy treatment had received medical recommendations upon discharge from the first or second chemotherapy treatment (181/281, 64%). Sixty-eight percent (123/181) of the parents who were given medical recommendations reported that their child did not follow the recommendations. Two main predictors were found for non-adherence: child resistance (111/123, 90%) and inadequate information (100/123, 81%). In the adherent group, 20% of the parents (n = 12/58) reported trust in their child's doctor while 14 percent 8/58 reported trust in the other health-care professionals. Corresponding numbers for the non-adherent group are 8/123 (7%) for both their child's doctor and other health-care professionals. Almost all of the parents expressed a lack of optimism towards the treatment (116/121, 96%), yet they reported an intention to continue with the treatment for two main reasons, for the sake of their child's life (70%) (P = 0.005) and worry that their child would die if they discontinued the treatment (81%) (P < 0.0001). CONCLUSION:Non-adherence to medical regimen is common among children diagnosed with cancer in BRIEF ARTICLE 25June 22, 2013|Volume 3|Issue 2| WJP|www.wjgnet.com Egypt, the main reasons being child resistance and inadequate information.© 2013 Baishideng. All rights reserved.Key words: Cancer; Adherence to medical regimen; Non-compliance; Patient-physician communication; Paediatric oncology; Psycho-oncology; Psychosocial Core tip: Ensuring adherence to a prescribed medication regimen is a complex problem, even in parts of the world where studies have been made. Such studies have not been made in the Arab World. Research has established that a holistic approach is essential if adherence is to be improved. We know that patient-physici...

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Loss to follow‐up of minorities, adolescents, and young adults on clinical trials: A report from the Children's Oncology Group

Puthenpura

et al. 2023

Cancer

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Background:The increasing number of childhood cancer survivors necessitates continued follow-up to monitor for long-term complications. Inequities in loss to follow-up for patients enrolled on pediatric clinical trials have not been well studied. Methods:This was a retrospective study of 21,084 patients residing in the United States enrolled on phase 2/3 and phase 3 Children's Oncology Group (COG) trials between January 1, 2000 and March 31, 2021. Rates of loss to follow-up to COG were evaluated using log-rank tests and multivariable Cox proportional hazards regression models with adjusted hazard ratios (HRs). Demographic characteristics included age at enrollment, race, ethnicity, and zip code level socioeconomic data.Results: Adolescent and young adult (AYA) patients 15-39 years old at diagnosis had an increased hazard of loss to follow-up compared to patients 0-14 years old (HR, 1.89; 95% confidence interval (CI), 1.76-2.02). In the overall cohort, non-Hispanic Blacks were found to have an increased hazard of loss to follow-up compared to non-Hispanic Whites (HR, 1.56; 95% CI, 1.43-1.70). Among AYAs, the highest loss to follow-up rates were among non-Hispanic Blacks (69.8% � 3.1%), patients on germ cell tumor trials (78.2% � 9.2%), and patients living in zip codes with a median household income ≤150% of the federal poverty line at diagnosis (66.7% � 2.4%).Conclusions: AYAs, racial and ethnic minority patients, and those living in lower socioeconomic status areas had the highest rates of loss to follow-up among clinical trial participants. Targeted interventions are warranted to ensure equitable followup and improved assessment of long-term outcomes.

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Treatment non-adherence in teenage and young adult patients with cancer

Cited by 135 publications

References 54 publications

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Adherence to medication: A nation-wide study from the Children’s Cancer Hospital, Egypt

Loss to follow‐up of minorities, adolescents, and young adults on clinical trials: A report from the Children's Oncology Group

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