Treatment Modality and Trends in Survival for Gallbladder Cancer: a Population-Based Study

Akhtar–Danesh, Noori; Akhtar-Danseh, Gileh-Gol; Seow, Hsien; Shakeel, Saad; Finley, Christian

doi:10.1007/s12029-020-00397-w

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…However, the rate of curative-intent surgery did not change during the study period, similarly as reported in a Swedish population-based study [29]. Patients' overall rate of proceeding to curativeintent surgery in our study was 19%, which is lower than the resection rate reported in West Sweden (37%), Netherlands (36%) or in Ontario (46%) [29,30,38]. Differences in curativeintent resection rates might reflect an actual difference in aggressiveness to surgical treatment but may also be explained by differences in defining curative-intent resection.…”

Section: Discussionsupporting

confidence: 81%

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Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study

Koppatz

Takala

Peltola

et al. 2021

Scandinavian Journal of Gastroenterology

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Introduction: Gallbladder cancer (GBC) is a rare malignancy in Western population with poor prognosis. This study aimed to investigate the trends in GBC incidence, treatment pattern, and survival in Finland. Methods: Patients diagnosed with primary GBC in a geographically defined area (Southern Finland Regional Cancer Center) during 2006-2017 were identified. Results: Final cohort included 270 patients with GBC. The incidence was 1.32/100,000 persons, and it decreased 6.8 cases per million personyears during the study period. One hundred fifty-one (56%) patients were diagnosed at Stage IV. Fifty-one patients (19%) underwent curative-intent resection with 96% R0-resection rate. The median overall survival was 7.1 months and 5-year overall survival 11.6% for all patients, and 67.7 months and 56.8% after curative-intent resection, respectively. No improvement was noted over time in overall survival in patients with GBC, or in subgroups of different stages of GBC. Conclusions: The incidence of GBC is slightly decreasing in Southern Finland, but survival has not improved over time.

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Section: Discussionsupporting

confidence: 81%

“…The 5-year overall survival was 12% in our study, which is similar to West Sweden (approximately 11%) and Netherlands (13%) albeit them having a higher curativeintent resection rates [29,30]. On the other hand, the 5-year overall survival was clearly higher in Ontario (25%), which also had very high curative-intent resection rate [38].…”

Section: Discussionsupporting

confidence: 75%

Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study

Koppatz

Takala

Peltola

et al. 2021

Scandinavian Journal of Gastroenterology

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Section: Introductionmentioning

confidence: 99%

“…Because the early stage of the disease is no different from a normal condition, it is often diagnosed in its late stage, and it has a poor prognosis 3 . With recent improvements in cancer surgery strategies, increased safety awareness of doctors, and changes in daily life, outcomes for patients with PGC have significantly improved 4,5 . A recent study found that the 5‐year mortality rate of patients with PGC in the United States was about 20.2% 6 …”

Section: Introductionmentioning

confidence: 99%

“…3 With recent improvements in cancer surgery strategies, increased safety awareness of doctors, and changes in daily life, outcomes for patients with PGC have significantly improved. 4,5 A recent study found that the 5-year mortality rate of patients with PGC in the United States was about 20.2%. 6 In 2019, 18.6 million people died from cardiovascular disease (CVD) worldwide, accounting for one-third of all deaths, and making it the most common cause of mortality.…”

Section: Introductionmentioning

confidence: 99%

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Competing risk analysis of cardiovascular death in patients with primary gallbladder cancer

Chen

Yuan

et al. 2022

Cancer Medicine

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Background Developments in medical technology are resulting in continuous decreases in the cancer mortality rate of patients with gallbladder cancer, while non‐cancer deaths in cancer patients are becoming more common. The main cause of this is cardiovascular mortality (CVM). The purpose of this study was to determine the CVM risk in patients with primary gallbladder cancer (PGC). Methods We extracted information on patients in the SEER database who were diagnosed with PGC from 2004 to 2015, compared CVM in patients with PGC with the general United States population, and calculated standardized mortality rates (SMRs) and the absolute excess risk. A competing risks model was used to identify and analyze the independent risk factors for cardiovascular death in patients with PGC. Results This study included 5925 patients, 247 of whom died from cardiovascular disease. The SMR of cardiovascular death in patients with PGC was 15.84 (95% confidence interval: 15.83–15.85), and the SMR was slightly lower in male than female patients. The competing risks analysis indicated that age, marital status, cancer cell differentiation, chemotherapy status, and year of diagnosis were risk factors for cardiovascular death in patients with PGC. Conclusions The CVM risk is considerably higher in patients with PGC than in the general population. It is therefore very necessary to apply cardioprotective interventions to patients with PGC.

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Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Franco,

Lau,

Liu

et al. 2024

Langenbecks Arch Surg

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The main purpose of this study is to explore the outcomes of patients found to have gallbladder cancer during investigation and diagnosis of acute cholecystitis. The incidence of primary gallbladder cancer co-existing in acute cholecystitis is not well defined in the literature, with anecdotal reports suggesting that they experience worse outcomes than patients with gallbladder cancer found incidentally. Methods A retrospective review of all patients with gallbladder cancer managed at the Canberra Health Service between 1998 and May 2022 were identified and reviewed. Results A total of 65 patients were diagnosed with primary gallbladder cancer during the study period with a mean age of 70.4 years (SD 11.4, range 59–81.8 years) and a female preponderance (74% versus 26%) with a ratio of 2.8. Twenty (31%) patients presented with acute calculus cholecystitis and were found to have a primary gallbladder cancer. This group of patients were older and predominantly female, but the difference was not statistically significant. The overall 5-year survival in the cohort was 20% (stage 1 63%, stage 2 23%, stage 3 16%, and stage 4 0%). There was no statistically significant difference in survival between those who presented with acute cholecystitis vs other presentations. Conclusions A third of the patients with gallbladder cancer presented with acute cholecystitis. There was no statistically significant difference in survival in those with bile spillage during cholecystectomy as well those presenting with acute cholecystitis.

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Treatment Modality and Trends in Survival for Gallbladder Cancer: a Population-Based Study

Cited by 6 publications

References 27 publications

Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study

Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study

Competing risk analysis of cardiovascular death in patients with primary gallbladder cancer

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

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