Treatment Modalities of the Covid-19 Pandemic Through Repurposed Drugs and Status of Vaccines

HUSSSAIN, MD SADIQUE; Mohit, .; PAMMA, PARUL; KUMARI, BABY

doi:10.22159/ijap.2021v13i2.40554

Cited by 8 publications

(4 citation statements)

References 138 publications

(153 reference statements)

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“…The aging population is thus a major concern in calculating mortality and suffering during the global coronavirus outbreak. 35 ►Table 1 classifies the CoVs symptoms. As a result, it can be asserted that the major aversive element in individuals with severe COVID-19 is aberrant and excessive ACE2 function.…”

Section: Epidemiology Clinical Features and Pathophysiology Of Covid-19mentioning

confidence: 99%

The Burden of Cardiovascular Diseases Due to COVID-19 Pandemic

Hussain

Sharma

2022

Thorac Cardiovasc Surg

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The coronavirus disease 2019 (COVID-19) is an infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that produces respiratory symptoms and has serious consequences for people's cardiovascular systems (CVS). It is a severe issue and a major task not only for health care experts but also for governments to contain this pandemic. SARS-CoV-2 is the seventh member of the human coronavirus family to be implicated in this zoonotic outbreak. COVID-19's CV interactions are comparable to those of SARS-CoV, Middle East respiratory syndrome (MERS-CoV), and influenza. Those who have COVID-19 and underlying cardiovascular diseases (CVDs) are at a higher risk of serious illness and mortality, and disease has been linked to several direct and indirect CV consequences. COVID-19 causes CVDs such as arrhythmias, cardiac arrest, cardiogenic shock, myocarditis, stress-cardiomyopathy, and acute myocardial damage (AMD) as a consequence of acute coronary syndrome. The provision of CV care may expose health care professionals to risk as they become hosts or vectors of viral transmission. It binds to the angiotensin-converting enzyme receptor, causing constitutional and pulmonary signs in the beginning, and then as the infection advances, it affects other organs such as the gastrointestinal tract, CVS, neurological system, and so on. COVID-19 mortality is increased by underlying CVDs comorbidities.

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Section: Epidemiology Clinical Features and Pathophysiology Of Covid-19mentioning

confidence: 99%

The Burden of Cardiovascular Diseases Due to COVID-19 Pandemic

Hussain

Sharma

2022

Thorac Cardiovasc Surg

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“…Vaccines are one of the most cost-effective and hence critical healthcare programs [21]. There are currently 136 vaccine candidates in clinical trials and 194 candidates in pre-clinical research against SARS-CoV-2 across the world.…”

Section: Types Of Vaccinementioning

confidence: 99%

Advances in the Adverse Effects of Covid-19 Vaccination and the Concept of Vaccine Development

Hussain

Singh

Dhingra

et al. 2022

JPRI

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Coronavirus disease-2019 (COVID-19) is an outbreak on a scale unseen in modern human history. More than two years after the outbreak began, there are 271 million fatalities and more than 5.32 million mortalities reported globally. Vaccination has been the most successful medical intervention in the last century to minimize mortality and suffering due to infectious illnesses. Only the discovery and dissemination of an effective vaccine will probably result at the end of this pandemic. Tremendous attempts have also been made to develop secure and convenient vaccinations. Vaccination is an efficient method of preventing viral illness, stopping its spread, and developing protective immunity. Improved understanding of protective immunity and significant advances in gene editing has enabled the development of a wide range of novel vaccines by manipulating sugars, RNA, proteins, and DNA. The development of attenuated mutants, the expression of prospective antigens in live vectors, and the purifying and direct production of antigens in novel systems have all greatly enhanced vaccination science. Several researchers have been working to assess the effectiveness and toxicity of potential vaccinations against new COVID-19. Furthermore, it is critical to assess the impact of immunization on the severity of illness. Vaccination is currently the most efficient method of regulating animal and human viral illnesses, either by avoiding fatality or drop in suffering. This review summaries several vaccinations developed by different countries. The details are taken and reviewed by a number of articles including research/review articles, systematic reviews and meta-analysis. The articles were selected randomly and different data was collected to present as a short review.

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“…Present scientific organization of COVID-19 contains of poison deterrence in addition switch events in addition helpful repair, as well as additional oxygen in addition motorized ventilatory provision as soon as designated [15]. Numerous repurposed medicates, together with antivirals, antibiotics, monoclonal antibodies, corticosteroids, and others, remained originate towards the activeness in contradiction of this novel COVID-19 [16]. Governments, private businesses, researchers, and non-profit organizations have been occupied solid towards generate a COVID-19 vaccine [16].…”

Section: Treatment Modalitiesmentioning

confidence: 99%

“…Numerous repurposed medicates, together with antivirals, antibiotics, monoclonal antibodies, corticosteroids, and others, remained originate towards the activeness in contradiction of this novel COVID-19 [16]. Governments, private businesses, researchers, and non-profit organizations have been occupied solid towards generate a COVID-19 vaccine [16]. The worldwide plague of COVID-19 takes faster the competition to discovery real deterrence in addition action intended for SARS-CoV-2 poison [6].…”

Section: Treatment Modalitiesmentioning

confidence: 99%

An Association between COVID-19 and Diabetes Mellitus

Bansod

Anjankar

2021

JPRI

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Coronaviruses are a large group of viruses accountable for initiating severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS), Common Cold, etc. Studies have found a certainly available development severity about covid epidemic over rising in blood glucose level sufferers. There is the effect of functioning dextrose equilibrium, rawness, change-resistant level together with a start regarding this peptide-aldosterone method (RAAS) caused by possible infective connection in the middle of SARS-CoV-2 along with insulin-dependent diabetes. Your chance regarding come to have extremely unwell against SARS-CoV-2 live probable via occurring minor whether you all are blood glucose level crop up controlled. Experience coronary illness either more difficulty over inclusion on rising in blood glucose level would intensify this likeliness on obtaining solemnly sick by SARS-CoV-2, similar to another fervid contamination, on account of additional compared to only situation build that solid as you all are physique directed toward opposing this contamination. Growing contamination would too expand swelling, either inner bump, rising humans accompanied by a rise in blood glucose level, above-target blood sugars can also be the cause of that, and more severe complications can happen due to that inflammation. Instead of the other side, recently developed rise in glucose blood level and extreme catabolic difficulties regarding the previous rise in blood glucose level, as well as ketoacidosis diabetic including non-ketotic hyperglycemia considering whichever unusually excessive shots regarding hypoglycaemic agent come about validate, turned out to be seen within sufferer of SARS-CoV-2. In Hindustan throughout this, another upsurge regarding this SARS-CoV-2, seeing that unparalleled gush over patient regarding black fungus took place were seen: resistance down-regulation give rise to Covid-19 along with this utilization regarding effective against a wide range of organisms along with glucocorticoids-specific convalescent which is a dully restrained rise in blood glucose level along the ketoacidosis—are to be expected be obliged to come up with up to mutiny. SARS-CoV-2 comes behind alongside black fungus shore extreme risk bloodshed rate along with opportune observation, fungicidal treatment, cruel incision, the usually surgical removal of lacerated left important element of this operation.

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Treatment Modalities of the Covid-19 Pandemic Through Repurposed Drugs and Status of Vaccines

Cited by 8 publications

References 138 publications

The Burden of Cardiovascular Diseases Due to COVID-19 Pandemic

The Burden of Cardiovascular Diseases Due to COVID-19 Pandemic

Advances in the Adverse Effects of Covid-19 Vaccination and the Concept of Vaccine Development

An Association between COVID-19 and Diabetes Mellitus

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