Treatment for Restless Legs Syndrome Secondary to Chronic Liver Disease: A Case Report

Oguri, Tetsuya; Sugiyama, Hanako; Hamano, Toshiaki; Tachibana, Naoko

doi:10.2169/internalmedicine.51.6853

Cited by 4 publications

(2 citation statements)

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“…12 Treatment of HE, administration of branched-chain amino acids, dietary protein restriction and levodopa have also been reported to improve RLS symptoms associated with CLD. 13 However, benzodiazepines and opiates should be used cautiously in CLD patients given their decreased hepatic metabolism and subsequent risk of precipitating HE. 14,15 The significant association between RLS, cirrhosis and history of HE in our cohort suggests these conditions may be aetiologically linked.…”

Section: Discussionmentioning

confidence: 99%

“…Effective pharmacotherapies are available for RLS and include iron replacement, dopaminergic agents and alpha‐2‐delta calcium channel ligands such as pregabalin or gabapentin . Treatment of HE, administration of branched‐chain amino acids, dietary protein restriction and levodopa have also been reported to improve RLS symptoms associated with CLD . However, benzodiazepines and opiates should be used cautiously in CLD patients given their decreased hepatic metabolism and subsequent risk of precipitating HE …”

Section: Discussionmentioning

confidence: 99%

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Prevalence of restless legs syndrome in a tertiary cohort of ambulant patients with chronic liver disease

Michael

Huang

Adams

et al. 2018

Internal Medicine Journal

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A cross-sectional survey of 188 ambulant patients with chronic liver disease was performed to determine the prevalence of restless legs syndrome (RLS) using a validated patient completed questionnaire. Patient responses were verified by standardised telephone interview. RLS was identified in 64 (34%) patients. Significantly, more patients with cirrhosis had RLS than patients without RLS (43.9 vs 23.3%, P = 0.003, respectively). Cirrhotic patients with a history of hepatic encephalopathy were also more likely to have RLS than patients without hepatic encephalopathy (odds ratio = 4.33, 95% confidence interval = 1.40-13.37, P = 0.011). Patients with chronic liver disease may be at risk for RLS; early detection and treatment may improve patient outcomes.

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