Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer

Kim, Young Jin; Kim, Chang‐Hyun

doi:10.3393/ac.2021.00920.0131

Cited by 24 publications

(13 citation statements)

References 63 publications

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“…However, the best treatment option remains controversial. Adjuvant hormonal therapy, sclerotherapy with tetracycline, and HIPEC has been suggested as treatment options [17] . However, it is believed that surgery with complete removal of cystic lesions is the only effective treatment, and provides the only chance for avoiding local recurrence.…”

Section: Discussionmentioning

confidence: 99%

Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report

Lee

Nahm

Kang

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report

Lee

Nahm

Kang

et al. 2022

International Journal of Surgery Case Reports

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“…Based on the consideration that biophysical changes of the thorax and a less hospitable environment for tuberculosis bacteria might have been the reason for the success of this unconventional approach, we theorize that our model of cell dehydration could have similar promising effects on PM. In patients with cancer diseases, the metastatic process in the peritoneal cavity is a critical factor for survival ( 25 ). Using physical principles in innovative treatments of PM and other surface malignancies seems promising and has been attempted several times ( 26 – 29 ).…”

Section: Discussionmentioning

confidence: 99%

The Onset of In-Vivo Dehydration in Gas -Based Intraperitoneal Hyperthermia and Its Cytotoxic Effects on Colon Cancer Cells

et al. 2022

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BackgroundPeritoneal metastasis (PM) is an ongoing challenge in surgical oncology. Current therapeutic options, including intravenous and intraperitoneal (i.p.) chemotherapies display limited clinical efficacy, resulting in an overall poor prognosis in affected patients. Combined hyperthermia and dehydration induced by a high-flow, gas-based i.p. hyperthermic procedure could be a novel approach in PM treatment. Our study is the first to evaluate the therapeutic potential of i.p. dehydration, hyperthermia, as well as the combination of both mechanisms in an in-vivo setting.MethodsFor this study, three swine were subjected to diagnostic laparoscopy under a high-flow air stream at 48°, 49° and 50°Celsius (C). Hygrometry of the in- and outflow airstream was measured to calculate surface evaporation and i.p. dehydration. To analyze the effects of this concept, in vitro colon cancer cells (HT-29) were treated with hyperthermia and dehydration. Cytotoxicity and cell viability were measured at different time intervals. Additionally, structural changes of dehydrated cells were analyzed using scanning electron microscopy.ResultsAccording to our results, both dehydration and hyperthermia were cytotoxic to HT-29 cells. However, while dehydration reduced cell viability, hyperthermia did not. However, dehydration effects on cell viability were significantly increased when combined with hyperthermia (p<0.01).ConclusionsChanges to the physiological milieu of the peritoneal cavity could significantly reduce PM. Therefore, limited dehydration of the abdominal cavity might be a feasible, additional tool in PM treatment. Further studies are required to investigate dehydration effects and their applicability in PM management.

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“…Chemotherapy is the major treatment for CRC that has spread to other organs, and surgery is only occasionally employed. However, with advancements in systemic therapy, increased use of genetic information, and the development of surgical techniques, more individuals with metastatic CRC can benefit from curative-intent surgical surgery [16][17][18].…”

Section: Development Surgical Treatment Of Metastatic Colorectal Cancermentioning

confidence: 99%

Update on Diagnosis and Treatment of Colorectal Cancer

Kim¹

2022

Ewha Med J

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The rate of colorectal cancer (CRC) has altered. Early-onset CRC patients are increasing, and it is one of the main causes of cancer-related death. Based on epidemiologic change, the CRC screening program needs to be changed. To increase compliance, non-invasive screening techniques are developed. Although CRC survival has increased, the oncologic prognosis of metastatic CRC is remains poor. Even in metastatic CRC, which is the most difficult to treat, attempts are being made to increase the survival rate by active surgical therapy with the creation of chemotherapeutic regimens and targeted treatment based on genomic information. Due to the introduction of aggressive chemotherapy regimens, targeted therapy based on genomic features, and improvements in surgical technique, the role of surgical treatment in metastatic CRC has expanded. Metastatic CRC surgery was indicated for liver, lung, and even peritoneal seeding. Local ablation therapy was also effectively used for liver and lung metastasis. Cytoreductive surgery and intraperitoneal chemotherapy were tried for peritoneal seeding and demonstrated good results in a subgroup of patients, although the right indication was carefully assessed. At the same time, one of the key goals of treatment for CRC was to maintain functional outcomes. Neoadjuvant treatment, in particular, helped rectal cancer patients preserve functional results while maintaining oncologic safety. Rectal cancer organ preservation techniques are now being researched heavily in a variety of neoadjuvant treatment settings, including immunotherapy and whole neoadjuvant therapy. Precision medicine based on patient and disease characteristics is currently being used for the diagnosis and treatment of CRC.

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Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer

Cited by 24 publications

References 63 publications

Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report

Benign multicystic mesothelioma of appendiceal origin treated by hyperthermic intraperitoneal chemotherapy: A case report

The Onset of In-Vivo Dehydration in Gas -Based Intraperitoneal Hyperthermia and Its Cytotoxic Effects on Colon Cancer Cells

Update on Diagnosis and Treatment of Colorectal Cancer

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