Treatment for peritoneal dialysis-associated peritonitis

Abstract

Analysis 1.2. Comparison 1 Intravenous (IV) versus intraperitoneal (IP) antibiotics, Outcome 2 Adverse events.. . Analysis 1.3. Comparison 1 Intravenous (IV) versus intraperitoneal (IP) antibiotics, Outcome 3 Infusion pain.. . Analysis 2.1. Comparison 2 Oral (drug A) versus intraperitoneal (drug A) antibiotics (same antibiotic), Outcome

Pharmacokinetics of Intraperitoneal and Intravenous Fosfomycin in Automated Peritoneal Dialysis Patients without Peritonitis

“…administration of antibiotics is superior to i.v. dosing (12). As expected, we detected a prolonged half-life in serum compared to that in patients with intact renal function (5).…”

Stability Test of Ampicillin Sodium Solutions in the Accufuser® Elastomeric Infusion Device Using HPLC: UV Method

“…For example, many patients practice peritoneal dialysis-peritonitis and intraperitoneal administration of antibiotics. This is superior to other intravenous therapies [20] and allows ongoing outpatient treatment, which shortens hospital admission which is beneficial to both patients and to health care system [1]. Therefore, reliable and widely available stability information of antibiotics in the Accufuser ® infusion device is clinically important.…”

Consensus Guidelines for the Prevention and Treatment of Catheter-Related Infections and Peritonitis in Pediatric Patients Receiving Peritoneal Dialysis: 2012 Update

“…Several controlled and uncontrolled studies with widely var ying inclusion criteria and procedural protocols have assessed the efficacy of fibrinolytic agents in resolving resistant and preventing recurrent infections (236)(237)(238)(239)(240)(241)(242)(243). A placebo-controlled trial showed no significant effect of urokinase when administered intraperitoneally (30 000 IU/L) as adjuvant therapy in antibiotic-resistant bacterial peritonitis (242).…”

“…Catheter exchange has been shown to be superior to urokinase in lowering treatment failure rates in relapsing or persistent peritonitis (237,243). Not surprisingly, that finding is especially true with respect to relapsing peritonitis related to a TI or intra-abdominal abscess, which always should be carefully ruled out in patients with relapsing peritonitis.…”

“…However, no properly conducted RCTs appear to have addressed definitive indications for, and timing of, catheter removal. In addition, the available evidence fails to indicate the optimal timing for insertion of a new PD catheter to replace a catheter that has been removed because of peritonitis (243). As demonstrated by the IPPR, treatment of most cases of peritonitis will result in marked clinical improvement within several days.…”