Treatment for overactive bladder

Yang, Deyu; Zhao, Liu-Ni; Qiu, Mingxing

doi:10.1097/md.0000000000025941

Cited by 10 publications

(2 citation statements)

References 35 publications

(109 reference statements)

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“…18,19 To address these issues, several studies have examined the possibility of using a home TENS unit (transcutaneous tibial nerve stimulation [TTNS]) with electrode placement along the ankle to target the posterior tibial nerve, which has shown results comparable to PTNS. [42][43][44] A small randomized trial also showed that TTNS was noninferior for maintenance therapy after a 12-week PTNS program. 45 Generally, TTNS uses electrode patches placed on the ankle, but treatment at the plantar surface of the heel is potentially more comfortable and reproducible.…”

Section: N Original Researchmentioning

confidence: 99%

“…In addition, the broad-based contact of the electrodes to the plantar surface requires less precision and is less prone to user error than placement near the medial maleolus. Although a home TENS unit to deliver transcutaneous posterior tibial nerve stimulation can be set to 20-Hz, 200-μs pulse width square wave forms, 42,43 the SoleStim pulse characteristics (Fig. 2) are specifically designed to be more comfortable and avoid muscle tetany.…”

Section: N Original Researchmentioning

confidence: 99%

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Pilot Study of a Novel At-Home Posterior Tibial Nerve System for Overactive Bladder Syndrome

Burton¹,

Sokol

2023

UROGC

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Importance Urgency urinary incontinence and overactive bladder are common conditions. Third-line therapies are often underutilized because of either being too invasive or being burdensome for the patient. Objective We aimed to determine the efficacy and acceptability of a noninvasive, home-based posterior tibial nerve treatment system for the treatment of overactive bladder syndrome. Study Design In this pilot study, 10 postmenopausal women with urgency urinary incontinence were given the SoleStim System for home-based posterior tibial nerve stimulation. Symptoms at baseline and completion of the 8-week study were determined by 3-day voiding diary and quality-of-life questionnaire (Overactive Bladder Questionnaire) to assess for reduction in incontinence episodes. Results All patients were 100% adherent to the SoleStim System application over the 8-week period and reported statistically significant reductions in the mean number of voids (−16.3%, P = 0.022), urgency episodes (−31.2%, P = 0.02), and urgency urinary incontinence episodes (−31.4%, P = 0.045). Forty percent of participants reported a decrease of ≥50% in their urgency urinary incontinence episodes. SoleStim was scored a value of 1.8 ± 2.0 (mean ± SD) on a 10-point usability scale, indicating that it was highly acceptable from an ease-of-use perspective. No adverse events were reported. Conclusions The SoleStim System improved key overactive bladder (frequency, urgency, and urgency urinary incontinence episodes) and quality-of-life metrics. The results from this pilot study suggest that the SoleStim System may be a safe, effective, and highly acceptable at-home overactive bladder therapy.

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Section: N Original Researchmentioning

confidence: 99%

Section: N Original Researchmentioning

confidence: 99%

Pilot Study of a Novel At-Home Posterior Tibial Nerve System for Overactive Bladder Syndrome

Burton¹,

Sokol

2023

UROGC

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Effects of posterior tibial nerve stimulation (PTNS) on lower urinary tract dysfunction: An umbrella review

Tahmasbi,

Salehi‐Pourmehr,

Naseri

et al. 2023

Neurourology and Urodynamics

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BackgroundLower urinary tract dysfunction (LUTD) is a common, troublesome condition that often negatively affects patients' quality of life. Current literature has long been interested in how posterior tibial nerve stimulation (PTNS) can affect this condition.AimTo extensively and systematically explore how PTNS affects LUTD based on the most recent systematic reviews.MethodsA systematic search was conducted in PubMed, Scopus, Web of Science, and Embase according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. All the systematic reviews, with or without meta‐analysis that assessed the effects of PTNS on LUTD were retrieved. The quality of the included studies was assessed using the Joanna Briggs Institute tool, and analysis was conducted using the Comprehensive Meta‐Analysis version 3 tool.ResultsFrom a total of 3077 citations, 20 systematic reviews entered this study, and 13 of them included meta‐analysis. The population of studies varied vastly, for instance, some studies included only children or women while other focused on a specific pathology like multiple sclerosis‐induced neurogenic LUTD. The majority of included studies reported an overall improvement in LUTD following percutaneous PTNS, although admitting that these results were derived from moderate to low‐quality evidence.ConclusionThe findings of this thorough umbrella review showed that the positive benefits of PTNS in treating LUTD are currently supported by low‐quality evidence, and it is crucial to interpret them with great care.

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Home-based transcutaneous tibial nerve stimulation for overactive bladder syndrome: a randomized, controlled study

Cava¹,

Orlin

2022

Int Urol Nephrol

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Purpose Transcutaneous posterior tibial nerve stimulation (TPTNS) for the treatment of overactive bladder syndrome (OAB), with or without urge urinary incontinence (UUI) using electrodes imbedded in the fabric of a conventional sock and an attachable battery-operated stimulation device (ZIDA ® —Exodus Innovations, Sufa, Israel), was compared for effectiveness and safety to a sham procedure in a prospective, blinded, randomized, controlled trial. Methods Forty patients with diagnosed with OAB were recruited from a single site. There were two groups: a treatment group (21 patients, mean age 64), which used an active ZIDA ® activation device (ZIDA) and a sham control group (SCG, 19 patients, mean age 72) randomized in a 1:1 ratio. After individual fitting of the sock and face-to-face instruction in the use of the device, patients in both groups self-administered the treatment once weekly for 30 min at home for a duration of 12 weeks. Prior to randomization and in Week 12, patients completed two 3-day bladder diaries and a quality-of-life (QOL) survey. Treatment success was defined as at least a 50% reduction in urgency voids with or without incontinence or at least a 30% reduction in 24-h frequency from baseline to Week 12. The key secondary endpoint was change in QOL from baseline to Week 12. Results The success rate for the primary endpoint in the ZIDA group was 80% ( n = 16/20) versus 39% ( n = 7/18) in the SCG ( p = 0.02). For QOL, the least squares mean difference in change from baseline to Week 12 between the ZIDA and sham control arms total score was − 12.7 (95% CI − 20.2 to − 5.1). No significant adverse effects were observed. Conclusion TPTNS using the ZIDA home-based stimulation device offers a safe and effective treatment for patients with OAB syndrome and improves QOL. Trial regestration TRN: NCT04470765.

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Treatment for overactive bladder

Cited by 10 publications

References 35 publications

Pilot Study of a Novel At-Home Posterior Tibial Nerve System for Overactive Bladder Syndrome

Pilot Study of a Novel At-Home Posterior Tibial Nerve System for Overactive Bladder Syndrome

Effects of posterior tibial nerve stimulation (PTNS) on lower urinary tract dysfunction: An umbrella review

Home-based transcutaneous tibial nerve stimulation for overactive bladder syndrome: a randomized, controlled study

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