Treatment failure prediction for head-and-neck cancer radiation therapy

Rocha, Humberto; Khouri, Leila; Lopes, Mário; Dias, Joana; Ferreira, B.

doi:10.1016/j.canrad.2016.02.012

Cited by 6 publications

(4 citation statements)

References 19 publications

(36 reference statements)

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“…A). Nevertheless, age and T stage were traditionally considered as risk factors for adjuvant radiotherapy in clinical practice . As a result, we constructed a nomogram to predict the clinical outcomes of 307 HNSCC patients with radiotherapy, and variables including age, T staging, and N staging were taken into consideration (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Prediction of radiotherapy response with a 5‐microRNA signature‐based nomogram in head and neck squamous cell carcinoma

et al. 2018

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Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)‐based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation set (n = 153). In the training set, we combined the differential miRNA profiles with clinical outcomes, and LASSO regression model was applied to establish a 5‐miRNA signature. The prediction accuracy of the 5‐miRNA signature was further validated. In addition, target genes of these miRNAs were predicted, and Gene Ontology (GO) analysis as well as KEGG pathway analysis was executed. A 5‐miRNA signature including miR‐99a, miR‐31, miR‐410, miR‐424, and miR‐495 was identified. With a cutoff value of 1.2201 from Youden's index, the training set was divided into high‐risk and low‐risk groups, and the 5‐year overall survival was significantly different (30% vs. 73%, HR 3.65, CI 2.46–8.16; P < 0.0001). Furthermore, our 5‐miRNA signature revealed that only low‐risk group would benefit from radiotherapy. Then, a nomogram combining 5‐miRNA signature with clinical variables to predict radiotherapy response was constructed. The analysis of 108 target genes of these miRNAs revealed some potential mechanisms in HNSCC radiotherapy response for future investigations. In conclusion, the 5‐miRNA signature‐based nomogram is useful in predicting radiotherapy response in HNSCC and might become a promising tool to optimize radiation strategies.

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Section: Resultsmentioning

confidence: 99%

“…4A). Nevertheless, age and T stage were traditionally considered as risk factors for adjuvant radiotherapy in clinical practice [10,11]. As a result, The 5-miRNA signature was capable of predicting the OS in different clinicopathological factors.…”

Section: Establishment Of a Nomogram To Predict The Overall Survival ...mentioning

confidence: 99%

Prediction of radiotherapy response with a 5‐microRNA signature‐based nomogram in head and neck squamous cell carcinoma

et al. 2018

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“…Therefore, oncologic care for H&NC patients should focus on the importance of prognosis and prediction in decision making and treatment approaches that contribute to the best response and minimal toxicity of treatment [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

et al. 2023

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Head and neck cancer (H&NC) is a diverse category of tumors related to malignancies in the common aerodigestive pathway, with high metabolic rate, poor nutritional and treatment outcomes, and elevated mortality despite the best standard treatment. Herein, we focus on determining how the phase angle (PA) differs across sex as a predictor of poor prognosis, low quality-of-life (QoL) scores, and mortality in patients with head and neck cancer. This follow-up study presents a sex-differential analysis in a prospective cohort of 139 head and neck cancer patients categorized by sex as male (n = 107) and female (n = 32). Patients were compared in terms of nutritional, biochemical, and quality-of-life indicators between low and normal PA in women (<3.9° (n = 14, 43.75%) and ≥3.9°) and men (<4.5° (n = 62, 57.9%) and ≥4.5°). Our results show that most patients were in locally advanced clinical stages (women: n = 21 (65.7%); men: n = 67 (62.6%)) and that patients with low PA had a lower punctuation in parameters such as handgrip strength, four-meter walking speed, albumin, C-reactive protein (CRP), and CRP/albumin ratio (CAR), as well as the worst QoL scores in functional and symptomatic scales in both the male and female groups. A comparison between sexes revealed significant disparities; malnourishment and tumor cachexia related to an inflammatory state was more evident in the women’s group.

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“…The aim of the latter is to improve the quality of patient's life without actually curing the primary disease. 5 Dentists have an important role in screening the head & neck cancer patient at an early stage. Patients who present with leukoplakia, especially speckled leukoplakia on buccal mucosa, gingivae, palate or floor of mouth, should be investigated thoroughly and referred to the specialist without any delay.…”

Section: Introductionmentioning

confidence: 99%

Topical Fluorides for Head and Neck Cancer Patients Subjected to Surgical Resection and Radiation Therapy in Resource Restraint Settings

Sheikh

Khan

Tabassum

2020

J Coll Physicians Surg Pak

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Patients undergoing surgical resection and ionizing radiations for the treatment of head and cancer may lead a challenging life even after the cure of the disease; because these procedures can adversely affect the oral mucosa, salivary gland, bone, masticatory musculature, and the dentition. Especially, if major salivary glands are exposed to high dose radiation, an irreversible xerostomia may occur that can lead to rampant dental caries. Treatment of these complications demands high cost and time; and is often unaffordable for the patients in the resource constraint setting rendering them to compromise on their quality of life. The healthcare providers should work together in a team to prevent or manage these complications and improve the lives of the patients. This review paper focuses on the significance of low cost fluoride treatment for salvaging the dentition among patients who have had developed head and neck carcinoma and later got subjected to surgical resection and radiation therapy.

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Treatment failure prediction for head-and-neck cancer radiation therapy

Cited by 6 publications

References 19 publications

Prediction of radiotherapy response with a 5‐microRNA signature‐based nomogram in head and neck squamous cell carcinoma

Prediction of radiotherapy response with a 5‐microRNA signature‐based nomogram in head and neck squamous cell carcinoma

Phase Angle in Head and Neck Cancer: A Sex-Differential Analysis from Biological and Clinical Behavior to Health-Related Quality of Life

Topical Fluorides for Head and Neck Cancer Patients Subjected to Surgical Resection and Radiation Therapy in Resource Restraint Settings

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