Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series

Cabada, Miguel M.; López, Martha; Cruz, Maria Clara Pinto; Delgado, Jennifer R.; Hill, Virginia; White, A. Clinton

doi:10.1371/journal.pntd.0004361

Cited by 63 publications

(42 citation statements)

References 25 publications

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“…Gulhan and colleagues have also reported a case of a child in Turkey that was infected with F. hepatica and, did not respond to TCBZ treatment, although this report did not speculate as to the mode of infection with a potentially TCBZ‐resistant isolate. Similarly, Cabada and colleagues have reported a group of patients, infected by ingesting watercress in the Cusco region of Peru that failed to respond to multiple courses of triclabendazole. As with the Winkelhagen et al .…”

Section: Emergence Of Drug Resistant Parasites: a Threat To Animals Amentioning

confidence: 92%

A prospective view of animal and human Fasciolosis

Cwiklinski

O’Neill

Donnelly

et al. 2016

Parasite Immunology

159

104

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SummaryFasciolosis, a food‐borne trematodiasis, results following infection with the parasites, Fasciola hepatica and Fasciola gigantica. These trematodes greatly affect the global agricultural community, infecting millions of ruminants worldwide and causing annual economic losses in excess of US $3 billion. Fasciolosis, an important zoonosis, is classified by WHO as a neglected tropical disease with an estimated 17 million people infected and a further 180 million people at risk of infection. The significant impact on agriculture and human health together with the increasing demand for animal‐derived food products to support global population growth demonstrate that fasciolosis is a major One Health problem. This review details the problematic issues surrounding fasciolosis control, including drug resistance, lack of diagnosis and the threat that hybridization of the Fasciola species poses to future animal and human health. We discuss how these parasites may mediate their long‐term survival through regulation and modulation of the host immune system, by altering the host immune homeostasis and/or by influencing the intestinal microbiome particularly in respect to concurrent infections with other pathogens. Large genome, transcriptome and proteomic data sets are now available to support an integrated One Health approach to develop novel diagnostic and control strategies for both animal and human disease.

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Section: Emergence Of Drug Resistant Parasites: a Threat To Animals Amentioning

confidence: 92%

A prospective view of animal and human Fasciolosis

Cwiklinski

O’Neill

Donnelly

et al. 2016

Parasite Immunology

159

104

View full text Add to dashboard Cite

show abstract

“…Cure rates of 95% using the 10mg/kg dose have recently been described in children, with 100% cure rates using two doses of 7.5mg/kg (120) . Reports of resistance to triclabendazole in livestock are increasingly common, and more recently likely resistance in human fascioliasis has been detected in the Netherlands and Peru (121,122) . Evidence from animal studies suggests triclabendazole resistance may be overcome by coadministration with the enzyme inhibitor ketonazole (123) .…”

Section: For Clonorchis Sinensis Opisthorchis Viverrini and Opisthormentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

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“…Triclabendazole (TCBZ) is the drug of choice since its effective against juveniles and adult liver flukes, but resistance to this benzimidazole has emerged in livestock in different countries [11]. There have been recent reports of human fascioliasis refractive to TCBZ treatment in Peru and Chile [12, 13], highlighting a need for alternative drugs and treatments.…”

Section: Introductionmentioning

confidence: 99%

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

et al. 2017

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Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domesticated ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle. A total of 14,642 genes were predicted from the 1.14 GB genome of the liver fluke. Comparative genomics indicated that F. hepatica Oregon and related food-borne trematodes are metabolically less constrained than schistosomes and cestodes, taking advantage of the richer millieux offered by the hepatobiliary organs. Protease families differentially expanded between diverse trematodes may facilitate migration and survival within the heterogeneous environments and niches within the mammalian host. Surprisingly, the sequencing of Oregon and Uruguay F. hepatica isolates led to the first discovery of an endobacteria in this species. Two contigs from the F. hepatica Oregon assembly were joined to complete the 859,205 bp genome of a novel Neorickettsia endobacterium (nFh) closely related to the etiological agents of human Sennetsu and Potomac horse fevers. Immunohistochemical studies targeting a Neorickettsia surface protein found nFh in specific organs and tissues of the adult trematode including the female reproductive tract, eggs, the Mehlis’ gland, seminal vesicle, and oral suckers, suggesting putative routes for fluke-to-fluke and fluke-to-host transmission. The genomes of F. hepatica and nFh will serve as a resource for further exploration of the biology of F. hepatica, and specifically its newly discovered trans-kingdom interaction with nFh and the impact of both species on disease in ruminants and humans.

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Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series

Cited by 63 publications

References 25 publications

A prospective view of animal and human Fasciolosis

A prospective view of animal and human Fasciolosis

Human liver flukes

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

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