Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study

Abstract

Objectives To investigate whether there is evidence that an increasing proportion of HIV infected patients is starting to experience increases in viral load and decreases in CD4 cell count that are consistent with exhaustion of available treatment options

Triple-Class Virologic Failure in HIV-Infected Patients Undergoing Antiretroviral Therapy for Up to 10 Years

“…So, while multiple drugs from several new classes are now available (integrase inhibitors, fusion inhibitors and CCR5 antagonists), at least in highincome countries, life-long viral suppression and consequential low death rates cannot be assured indefinitely. Virologic failure of the three original classes represents a key stage in a patient's failure history and it is important to monitor the rate with which this is occurring in order to anticipate the continuing need for new drugs in the future [3][4][5][6][7][8][9][10][11][12] . Such prediction of future need is important in the light of the lengthy drug development process.…”

Aids

“…Sie sind aber auch häufig mit oft schweren kardiovaskulä-ren, hepatischen, renalen, neuropsychiatrischen und sexuell-dysfunktionalen unerwünschten Wirkungen verbunden [2,3,4,5,6]. Auch schlägt die Therapie nicht bei allen Personen an -Längs-schnittstudien verzeichnen eine kleine, aber wachsende Zahl an Patienten, bei denen keine der gängigen Medikationen mehr zu einer nachhaltigen Absenkung der Plasmaviruslast unter die Nachweisgrenze führt [7]. Neben dem medizinisch-therapeutischen Erfolg hat die Gabe von ART aber auch Konsequenzen für die Primärprävention: Die Verringerung der Viruslast senkt auch ganz erheblich die Wahrscheinlichkeit für eine Weitergabe des Virus in Risikosituationen.…”

Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998-2008

“…Tel: 1 39 338 259 6115; e-mail: ahnven@yahoo.it *See Appendix. DOI: 10.1111/j.1468-1293.2010.00866.x HIV Medicine (2011 r 2010 British HIV Association 174 and detectable viraemia [2,3] reflect the impact of the successful use of cART, together with increases in drug uptake [4]. The best predictor of disease progression is the current absolute CD4 cell count, but the patient's age, current HIV RNA viral load (VL) and pre-ART AIDS diagnoses have also been shown to play a significant role in disease progression [5,6].…”

“…The declining trends over time in the prevalence of immunosuppression and detectable viraemia [2,3] reflect the impact of the successful use of cART, together with increases in drug uptake [4].…”